Anticancer agent 93

Modify Date: 2024-01-16 09:42:14

Anticancer agent 93 Structure
Anticancer agent 93 structure
Common Name Anticancer agent 93
CAS Number 94205-22-8 Molecular Weight 315.71
Density N/A Boiling Point N/A
Molecular Formula C16H10ClNO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Anticancer agent 93


Anticancer agent 93 is a 4-Hydroxycoumarin derivative. Anticancer agent 93 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors[1].

 Names

Name Anticancer agent 93

 Anticancer agent 93 Biological Activity

Description Anticancer agent 93 is a 4-Hydroxycoumarin derivative. Anticancer agent 93 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors[1].
Related Catalog
In Vitro Anticancer agent 93 (compound 4h) (5-15 μM; 24 h) significantly inhibits A549 cell invasion by ~ 50%[1]. Anticancer agent 93 (15 μM; 24-72 h) significantly inhibits A549 cell migration[1]. Anticancer agent 93 (5-15 μM; 4 h) inhibits lung cancer cell motility by downregulating EMT markers[1]. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 5, 10, 15 μM Incubation Time: 24 hours Result: Decreased expression of N-cadherin and E-cadherin.
References

[1]. Zhou R, et, al. Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility. Sci Rep. 2022 Dec 14;12(1):21635.  

 Chemical & Physical Properties

Molecular Formula C16H10ClNO4
Molecular Weight 315.71
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