l-leucine-2-d1

Modify Date: 2024-01-09 16:18:51

l-leucine-2-d1 Structure
l-leucine-2-d1 structure
 Common Name l-leucine-2-d1
CAS Number 89836-93-1 Molecular Weight 132.17900
Density N/A Boiling Point N/A
Molecular Formula C6H12DNO2 Melting Point >300 °C(lit.)
MSDS Chinese Flash Point N/A

 Use of l-leucine-2-d1


L-Leucine-d1 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

 Names

Name l-leucine-2-d1
Synonym More Synonyms

 l-leucine-2-d1 Biological Activity

Description L-Leucine-d1 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

[3]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

[4]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

[5]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

[6]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

[7]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

[8]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

[9]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

[10]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

[11]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

[12]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

[13]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

[14]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

[15]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

[16]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

[17]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

[18]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

[19]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

[20]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

[21]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

[22]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

[23]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

[24]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

[25]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

 Chemical & Physical Properties

Melting Point >300 °C(lit.)
Molecular Formula C6H12DNO2
Molecular Weight 132.17900
Exact Mass 132.10100
PSA 63.32000
LogP 1.14470

 Synthetic Route

(S)-Z-2-[2H1]-Leu structure

(S)-Z-2-[2H1]-Leu

CAS#:57224-92-7

~86%

l-leucine-2-d1 Structure

l-leucine-2-d1

CAS#:89836-93-1
Literature: Mitulovi, Goran; Laemmerhofer, Michael; Maier; Lindner, Wolfgang Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 5 p. 449 - 461
L-leucine structure

L-leucine

CAS#:61-90-5

~62%

l-leucine-2-d1 Structure

l-leucine-2-d1

CAS#:89836-93-1
Literature: Faleev, N. G.; Ruvinov, S. B.; Saporovskaya, M. B.; Belikov, V. M.; Zakomyrdina, L. N.; et al. Tetrahedron Letters, 1990 , vol. 31, # 48 p. 7051 - 7054
dl-leucine-2-d1 structure

dl-leucine-2-d1

CAS#:282726-23-2

~%

l-leucine-2-d1 Structure

l-leucine-2-d1

CAS#:89836-93-1
Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 5 p. 449 - 461
Sodium 4-methyl-2-oxopentanoate structure

Sodium 4-methyl...

CAS#:4502-00-5

~%

D-LEUCINE-2-D structure

D-LEUCINE-2-D

CAS#:89836-92-0
l-leucine-2-d1 Structure

l-leucine-2-d1

CAS#:89836-93-1
Literature: Bulletin of the Chemical Society of Japan, , vol. 56, # 12 p. 3652 - 3656
L-leucine structure

L-leucine

CAS#:61-90-5

~%

D-LEUCINE-2-D structure

D-LEUCINE-2-D

CAS#:89836-92-0
l-leucine-2-d1 Structure

l-leucine-2-d1

CAS#:89836-93-1
Literature: Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 38, # 10 p. 2154 - 2156 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 10 p. 2341 - 2343
ethyl benzoyl-L-leucinate-2-d structure

ethyl benzoyl-L...

CAS#:1255087-82-1

~%

l-leucine-2-d1 Structure

l-leucine-2-d1

CAS#:89836-93-1
Literature: Organic and Biomolecular Chemistry, , vol. 9, # 23 p. 7983 - 7985

 Synonyms

homoserine lactone*HBr
(S)-2-[2H1]-Leu
L-homoserine lactone hydrobromide
(S)-2-amino-2-deuterio-4-methyl-pentanoic acid
L-homoserine lactone HBr
(S)-3-Aminodihydrofuran-2(3H)-one hydrobromide
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