Naloxonazine dihydrochloride
Modify Date: 2024-01-03 02:12:09
Naloxonazine dihydrochloride structure
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Common Name | Naloxonazine dihydrochloride | ||
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| CAS Number | 82824-01-9 | Molecular Weight | 650.76300 | |
| Density | 1.12g/cm3 | Boiling Point | 433.7ºC at 760 mmHg | |
| Molecular Formula | C38H42N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 216.1ºC | |
Use of Naloxonazine dihydrochlorideNaloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function[1]. |
| Name | Naloxonazine dihydrochloride,Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene]hydrazinedihydrochloride |
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| Synonym | More Synonyms |
| Description | Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function[1]. |
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| Related Catalog | |
| In Vitro | Naloxonazine(0-50 μM, 24-72 h) 对细胞内 Leishmania donovani 的无鞭毛体阶段具有抑制活性，其最大抑制浓度 GI50为3.45 μM。而对 THP-1 宿主细胞的 GI50为 34 μM[1]。 Naloxonazine(10 μM, 4-72 h)可以抑制寄生虫细胞内生长，处理 24 h 可以抑制 70%，处理 72 h可以抑制 95%[1]。 Naloxonazine(10 μM, 4 or 24-72 h)导致 vATPase亚基 (ATP6V0C和TCIRG1) 和肌动蛋白 (ACTB) 基因及蛋白表达水平上调，并且影响了宿主细胞的细胞内酸性区室[1]。 |
| In Vivo | Naloxonazine (0-15 mg/kg, i.p., 20 h)在雄性 Wistar大鼠中，当剂量为 15 mg/kg 时，(olfactory discriminative stimulus)S+/CS+ 相关反应显著降低约 55%，由 14.63 降至 6.82。而在(olfactory stimulus)S-/CS-刺激条件下观察到更大的行为抑制，反应率降低 66%，从 9.00 降至 3.00[2]。 |
| References |
| Density | 1.12g/cm3 |
|---|---|
| Boiling Point | 433.7ºC at 760 mmHg |
| Molecular Formula | C38H42N4O6 |
| Molecular Weight | 650.76300 |
| Flash Point | 216.1ºC |
| Exact Mass | 650.31000 |
| PSA | 130.58000 |
| LogP | 3.15100 |
| Index of Refraction | 1.612 |
| WGK Germany | 3 |
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| NALOXONAZINE DIHYDROCHLORIDE OPIOID ANTA GONIST |
| NALOXONAZINE DIHYDROCHLORIDE |
| NALOXONAZINE 2HCL |
| naloxonazine |