DL-Mevalonolactone-d7

Modify Date: 2024-01-04 11:41:13

DL-Mevalonolactone-d7 Structure
DL-Mevalonolactone-d7 structure
Common Name DL-Mevalonolactone-d7
CAS Number 347840-19-1 Molecular Weight 137.18500
Density N/A Boiling Point N/A
Molecular Formula C6H3D7O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DL-Mevalonolactone-d7


DL-Mevalonolactone-d7 ((±)-Mevalonolactone-d7) is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

 Names

Name dl-mevalonolactone-4,4,5,5,6,6,6-d7

 DL-Mevalonolactone-d7 Biological Activity

Description DL-Mevalonolactone-d7 ((±)-Mevalonolactone-d7) is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310.

[3]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.

 Chemical & Physical Properties

Molecular Formula C6H3D7O3
Molecular Weight 137.18500
Exact Mass 137.10700
PSA 46.53000
LogP 0.07440