(S)-TNG260
Modify Date: 2024-01-01 06:21:54
(S)-TNG260 structure
|
Common Name | (S)-TNG260 | ||
|---|---|---|---|---|
| CAS Number | 2935964-93-3 | Molecular Weight | 383.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H18FN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (S)-TNG260(S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing. |
| Name | (S)-TNG260 |
|---|
| Description | (S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C20H18FN3O2S |
|---|---|
| Molecular Weight | 383.44 |