TH-Z827

Modify Date: 2025-08-26 17:12:51

TH-Z827 structure	Common Name	TH-Z827
	CAS Number	2847881-81-4	Molecular Weight	498.66
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₈N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TH-Z827

TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM[1].

Name	TH-Z827

Description	TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRAS(G12D):2.4 μM (IC50)
References	[1]. Zhongwei Mao, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5.

Molecular Formula	C₃₀H₃₈N₆O
Molecular Weight	498.66

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