TH-Z827

Modify Date: 2024-01-17 11:33:45

TH-Z827 Structure
TH-Z827 structure
 Common Name TH-Z827
CAS Number 2847881-81-4 Molecular Weight 498.66
Density N/A Boiling Point N/A
Molecular Formula C30H38N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TH-Z827


TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM[1].

 Names

Name TH-Z827

 TH-Z827 Biological Activity

Description TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM[1].
Related Catalog
Target

KRAS(G12D):2.4 μM (IC50)

References

[1]. Zhongwei Mao, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5.  

 Chemical & Physical Properties

Molecular Formula C30H38N6O
Molecular Weight 498.66
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Chemsrc provides TH-Z827(CAS#:2847881-81-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of TH-Z827 are included as well.>> amp version: TH-Z827

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