TH-Z827

Names

[ Name ]:
TH-Z827

Biological Activity

[Description]:

TH-Z827 is a mutant selective KRAS(G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS(WT) or KRAS(G12C). TH-Z827 blocked the KRAS(G12D)-CRAF interaction with an IC50 value of 42 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRAS(G12D):2.4 μM (IC50)

[References]

[1]. Zhongwei Mao, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₈N₆O

[ Molecular Weight ]:
498.66

Related Compounds

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