DBCO-PEG4-VC-PAB-MMAE

Modify Date: 2024-01-24 23:00:59

DBCO-PEG4-VC-PAB-MMAE Structure
DBCO-PEG4-VC-PAB-MMAE structure
Common Name DBCO-PEG4-VC-PAB-MMAE
CAS Number 2129164-91-4 Molecular Weight 1658.03
Density N/A Boiling Point N/A
Molecular Formula C88H128N12O19 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DBCO-PEG4-VC-PAB-MMAE


DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization[1].

 Names

Name DBCO-PEG4-VC-PAB-MMAE

 DBCO-PEG4-VC-PAB-MMAE Biological Activity

Description DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization[1].
Related Catalog
Target

Duocarmycins

References

[1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.

 Chemical & Physical Properties

Molecular Formula C88H128N12O19
Molecular Weight 1658.03

 Safety Information

Hazard Codes Xi