MNK8
Modify Date: 2024-01-13 11:07:10
MNK8 structure
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Common Name | MNK8 | ||
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| CAS Number | 2055078-49-2 | Molecular Weight | 252.27 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H12N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MNK8MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1]. |
| Name | MNK8 |
|---|
| Description | MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1]. |
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| Related Catalog | |
| Target |
STAT3 Bcl-2 |
| In Vitro | MNK8 (50 μM, 0-48 h) increases Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1[1]. |
| References |
| Molecular Formula | C15H12N2O2 |
|---|---|
| Molecular Weight | 252.27 |