Tengonermin

Modify Date: 2024-04-06 10:39:27

Tengonermin Structure
Tengonermin structure
Common Name Tengonermin
CAS Number 1960461-99-7 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tengonermin


Tengonermin (ARENEGYR) is a vascular-targeting agent consisting of the human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. Tengonermin increases penetration of intratumoral chemotherapy and T-cell infiltration by modifying the tumour microenvironment[1][2].

 Names

Name Tengonermin

 Tengonermin Biological Activity

Description Tengonermin (ARENEGYR) is a vascular-targeting agent consisting of the human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. Tengonermin increases penetration of intratumoral chemotherapy and T-cell infiltration by modifying the tumour microenvironment[1][2].
Related Catalog
In Vitro NGR-hTNF 是一种实体瘤治疗剂,通过 NGR 基序特异性靶向血管生成肿瘤血管[1]。
References

[1]. Valentinis B, et, al. Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling. Int J Mol Sci. 2019 Sep 12;20(18):4511.  

[2]. Gregorc V, et, al. NGR-hTNF in combination with best investigator choice in previously treated malignant pleural mesothelioma (NGR015): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol. 2018 Jun;19(6):799-811.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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