1960461-99-7

1960461-99-7 structure

Name: Tengonermin
Chemical Name: Tengonermin
CAS Number: 1960461-99-7
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Cancer
Create Date: 2023-01-30 09:30:35
Modify Date: 2024-04-06 10:39:27
Tengonermin (ARENEGYR) is a vascular-targeting agent consisting of the human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. Tengonermin increases penetration of intratumoral chemotherapy and T-cell infiltration by modifying the tumour microenvironment[1][2].

Name	Tengonermin

Description	Tengonermin (ARENEGYR) is a vascular-targeting agent consisting of the human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. Tengonermin increases penetration of intratumoral chemotherapy and T-cell infiltration by modifying the tumour microenvironment[1][2].
Related Catalog	Research Areas >> Cancer
In Vitro	NGR-hTNF 是一种实体瘤治疗剂，通过 NGR 基序特异性靶向血管生成肿瘤血管[1]。
References	[1]. Valentinis B, et, al. Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling. Int J Mol Sci. 2019 Sep 12;20(18):4511. [2]. Gregorc V, et, al. NGR-hTNF in combination with best investigator choice in previously treated malignant pleural mesothelioma (NGR015): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol. 2018 Jun;19(6):799-811.

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