Envonalkib citrate

Modify Date: 2024-01-02 04:43:10

Envonalkib citrate structure	Common Name	Envonalkib citrate
	CAS Number	1867204-56-5	Molecular Weight	698.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₄Cl₂FN₅O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Envonalkib citrate

Envonalkib citrate is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib citrate can be used for the research of non-small cell lung cancer[1].

Name	Envonalkib citrate

Description	Envonalkib citrate is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib citrate can be used for the research of non-small cell lung cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Target	IC50: 1.96 nM (WT-ALK), 35.1 nM (mutated L1196M-ALK), 61.3 nM (mutated G1269S-ALK)[1]
In Vivo	Envonalkib citrate (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts[1].
References	[1]. Feng G, et, al. Pyridine-substituted 2-aminopyridine protein kinase inhibitors. WO2016015676A1.

Molecular Formula	C₃₀H₃₄Cl₂FN₅O₉
Molecular Weight	698.52

Envonalkib citrate

Use of Envonalkib citrate

Names

Envonalkib citrate Biological Activity

Chemical & Physical Properties