1621519-26-3
1621519-26-3 structure
- Name: Envonalkib
- Chemical Name: Envonalkib
- CAS Number: 1621519-26-3
- Molecular Formula: C24H26Cl2FN5O2
- Molecular Weight: 506.40
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
- Create Date: 2022-03-25 21:05:48
- Modify Date: 2024-01-08 16:40:39
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Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used for the research of non-small cell lung cancer[1].
| Name | Envonalkib |
|---|
| Description | Envonalkib is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib can be used for the research of non-small cell lung cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.96 nM (WT-ALK), 35.1 nM (mutated L1196M-ALK), 61.3 nM (mutated G1269S-ALK)[1] |
| In Vivo | Envonalkib (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts[1]. |
| References |
[1]. Feng G, et, al. Pyridine-substituted 2-aminopyridine protein kinase inhibitors. WO2016015676A1. |
| Molecular Formula | C24H26Cl2FN5O2 |
|---|---|
| Molecular Weight | 506.40 |