Sparsentan-d5

Modify Date: 2024-02-04 21:15:43

Sparsentan-d5 structure	Common Name	Sparsentan-d5
	CAS Number	1801597-09-0	Molecular Weight	597.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₅D₅N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Sparsentan-d5

Sparsentan-d5 is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].

Name	Sparsentan-d5

Description	Sparsentan-d5 is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Murugesan N, et al. Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. J Med Chem. 2005 Jan 13;48(1):171-9.

Molecular Formula	C₃₂H₃₅D₅N₄O₅S
Molecular Weight	597.78