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1801597-09-0

1801597-09-0 structure

1801597-09-0 structure

Name: Sparsentan-d5
Chemical Name: Sparsentan-d5
CAS Number: 1801597-09-0
Molecular Formula: C₃₂H₃₅D₅N₄O₅S
Molecular Weight: 597.78
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2022-08-23 12:54:13
Modify Date: 2024-02-04 21:15:43
Sparsentan-d5 is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].

Name	Sparsentan-d5

Description	Sparsentan-d5 is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Murugesan N, et al. Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. J Med Chem. 2005 Jan 13;48(1):171-9.

Molecular Formula	C₃₂H₃₅D₅N₄O₅S
Molecular Weight	597.78