TAPI 0

Modify Date: 2024-01-22 17:15:55

TAPI 0 structure	Common Name	TAPI 0
	CAS Number	163958-73-4	Molecular Weight	456.53
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₂N₄O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS06	Signal Word	Danger

Use of TAPI 0

TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing[1][2].

Name	TAPI 0
Synonym	More Synonyms

Description	TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 100 nM (TACE)[2]
In Vitro	TAPI-0 inhibits peptide deformylase (PDF) with an IC50 of 18 nM. TAPI-0 suppresses chlamydial growth by targeting the bacterial PDF[1].
References	[1]. Amit Balakrishnan, et al. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J Biol Chem. 2006 Jun 16;281(24):16691-9. [2]. Shiori Haga, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5.

Density	1.2±0.1 g/cm3
Molecular Formula	C₂₄H₃₂N₄O₅
Molecular Weight	456.53
Exact Mass	456.237274
LogP	1.31
Index of Refraction	1.587
Water Solubility	Soluble to 10 (mg/mL) in DMSO

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310 + P330
RIDADR	UN 2811 6.1 / PGIII

N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide

TAPI-0

TNF-α Protease Inhibitor-0

N-(R)-(2-(Hydroxyaminocarbonyl)Methyl)-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine amide

MFCD02684279

TNF-α Processing Inhibitor-0

TAPI 0

Use of TAPI 0

Names

TAPI 0 Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms