PF-06455943

Modify Date: 2024-04-03 13:54:13

PF-06455943 structure	Common Name	PF-06455943
	CAS Number	1527474-15-2	Molecular Weight	323.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₄FN₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PF-06455943

PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD)[1][2].

Name	PF-06455943

Description	PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC50 value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD)[1][2].
Related Catalog	Signaling Pathways >> Autophagy >> LRRK2 Research Areas >> Neurological Disease
In Vitro	PF-06455943 (Compound 22) has inhibition activity for LRRK2 with IC50 values of 3 nM (WT), 9 nM (G2019S) and 20 nM (cellular WCA), respectively[1].

Molecular Formula	C₁₇H₁₄FN₅O
Molecular Weight	323.32

PF-06455943

Use of PF-06455943

Names

PF-06455943 Biological Activity

Chemical & Physical Properties