LTD4 antagonist 1

Modify Date: 2024-01-03 13:13:06

LTD4 antagonist 1 Structure
LTD4 antagonist 1 structure
Common Name LTD4 antagonist 1
CAS Number 136564-67-5 Molecular Weight 615.66
Density N/A Boiling Point N/A
Molecular Formula C31H32F3N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LTD4 antagonist 1


LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.

 Names

Name LTD4 antagonist 1

 LTD4 antagonist 1 Biological Activity

Description LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.
Related Catalog
Target

LTD4:0.57 nM (Ki)

In Vitro LTD4 antagonist 1 (Compound 38b) exhibits a Ki of 0.57 nM for displacement of [3H]LTD4 on guinea pig lung membranes, a pKB of 9.93±0.14 versus LTE4 on guinea pig trachea[1].
In Vivo LTD4 antagonist 1 (Compound 38b) exhibits a po ED50/iv ED50 of 1.44 and 0.036 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs[1].
References

[1]. Robert T. Jacobs, et al. Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[((2R)-2-Methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methylindol-3-yl]methyl]-3methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a Potent, Orally Active Antagonist of Leukotrienes D4 and E4. Journal of Medicinal Chemistry (1994), 37(9), 1282-97.

 Chemical & Physical Properties

Molecular Formula C31H32F3N3O5S
Molecular Weight 615.66