(R)-Pralatrexate

Modify Date: 2025-09-16 19:03:11

(R)-Pralatrexate Structure
(R)-Pralatrexate structure
 Common Name (R)-Pralatrexate
CAS Number 1320211-70-8 Molecular Weight 477.47300
Density N/A Boiling Point N/A
Molecular Formula C23H23N7O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (R)-Pralatrexate


(R)-Pralatrexate is the (R)-enantiomer of Pralatrexate (HY-10446). Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor[1].

 Names

Name (2S)-2-[[4-[(1R)-1-[(2,4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic acid
Synonym More Synonyms

 (R)-Pralatrexate Biological Activity

Description (R)-Pralatrexate is the (R)-enantiomer of Pralatrexate (HY-10446). Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor[1].
Related Catalog
References

[1]. Enrica Marchi, et al. Pralatrexate Is Synergistic With the Proteasome Inhibitor Bortezomib in in Vitro and in Vivo Models of T-cell Lymphoid Malignancies. Clin Cancer Res. 2010 Jul 15;16(14):3648-58.  

 Chemical & Physical Properties

Molecular Formula C23H23N7O5
Molecular Weight 477.47300
Exact Mass 477.17600
PSA 207.30000
LogP 2.53490
InChIKey OGSBUKJUDHAQEA-ZBFHGGJFSA-N
SMILES C#CCC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1

 Synonyms

PDX-10b
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Chemsrc provides (R)-Pralatrexate(CAS#:1320211-70-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of (R)-Pralatrexate are included as well.>> amp version: (R)-Pralatrexate

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