(R)-Pralatrexate

Names

[ CAS No. ]:
1320211-70-8

[ Name ]:
(R)-Pralatrexate

[Synonym ]:
PDX-10b

Biological Activity

[Description]:

(R)-Pralatrexate is the (R)-enantiomer of Pralatrexate (HY-10446). Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Enrica Marchi, et al. Pralatrexate Is Synergistic With the Proteasome Inhibitor Bortezomib in in Vitro and in Vivo Models of T-cell Lymphoid Malignancies. Clin Cancer Res. 2010 Jul 15;16(14):3648-58.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₃N₇O₅

[ Molecular Weight ]:
477.47300

[ Exact Mass ]:
477.17600

[ PSA ]:
207.30000

[ LogP ]:
2.53490

Related Compounds

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