URAT1&XO inhibitor 2

Modify Date: 2024-01-24 16:22:55

URAT1&XO inhibitor 2 Structure
URAT1&XO inhibitor 2 structure
Common Name URAT1&XO inhibitor 2
CAS Number 1239488-96-0 Molecular Weight 322.15
Density N/A Boiling Point N/A
Molecular Formula C14H12BrNO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of URAT1&XO inhibitor 2


URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of xanthine oxidase and URAT1, with IC50 of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a Ki value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia[1].

 Names

Name URAT1&XO inhibitor 2

 URAT1&XO inhibitor 2 Biological Activity

Description URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of xanthine oxidase and URAT1, with IC50 of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a Ki value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia[1].
Related Catalog
References

[1]. Hu Q, et al. (E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1. Biomed Pharmacother. 2017 Feb;86:88-94.  

 Chemical & Physical Properties

Molecular Formula C14H12BrNO3
Molecular Weight 322.15
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