URAT1&XO inhibitor 2

Names

[ Name ]:
URAT1&XO inhibitor 2

Biological Activity

[Description]:

URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of xanthine oxidase and URAT1, with IC50 of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a Ki value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> URAT1

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[References]

[1]. Hu Q, et al. (E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1. Biomed Pharmacother. 2017 Feb;86:88-94.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₂BrNO₃

[ Molecular Weight ]:
322.15

Related Compounds

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