Fmoc-His(Trt)-OH-15N3

Modify Date: 2024-01-18 10:00:20

Fmoc-His(Trt)-OH-15N3 Structure
Fmoc-His(Trt)-OH-15N3 structure
Common Name Fmoc-His(Trt)-OH-15N3
CAS Number 1217696-12-2 Molecular Weight 622.69
Density N/A Boiling Point N/A
Molecular Formula C40H3315N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fmoc-His(Trt)-OH-15N3


Fmoc-His(Trt)-OH-15N3 is the 15N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].

 Names

Name Fmoc-His(Trt)-OH-15N3

 Fmoc-His(Trt)-OH-15N3 Biological Activity

Description Fmoc-His(Trt)-OH-15N3 is the 15N labeled Fmoc-His(Trt)-OH[1]. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.

 Chemical & Physical Properties

Molecular Formula C40H3315N3O4
Molecular Weight 622.69