Tibenelast sodium

Modify Date: 2024-01-06 14:19:00

Tibenelast sodium structure	Common Name	Tibenelast sodium
	CAS Number	105102-18-9	Molecular Weight	288.29500
	Density	N/A	Boiling Point	440.8ºC at 760mmHg
	Molecular Formula	C₁₃H₁₃NaO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	220.4ºC

Use of Tibenelast sodium

Tibenelast sodium is a phosphodiesterase inhibitor.

Name	sodium,5,6-diethoxy-1-benzothiophene-2-carboxylate
Synonym	More Synonyms

Description	Tibenelast sodium is a phosphodiesterase inhibitor.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	phosphodiesterase[1]
In Vitro	The effect of the phosphodiesterase inhibitor Tibenelast, and placebo on isoproterenol-induced changes in heart rate, cAMP and norepinephrine levels in normal male volunteers is studied. Tibenelast increases the heart rate response to isoproterenol infusion, whereas norepinephrine and cAMP levels are not different in any treatment[1].
In Vivo	Tibenelast is a potent orally active compound against anaphylactic shock induced by high dose antigen aerosol. When a lower aerosol challenge (0.05 mg/mL) is employed, bronchoconstriction is observed with a concomitant increase in lung resistance (RL) and a fall in dynamic compliance (Cdyn). Tibenelast at 25 mg/kg p.o. prevents these changes. Tibenelast is 10 times more potent than Aminophylline by i.v. administration; normalization of pulmonary function is achieved at 1 mg/kg i.v. Tibenelast is synergistic with epinephrine. The oral dose response curve of Tibenelast is enhanced with the co-administration of epinephrine. Tibenelast may be of significant value in the treatment of asthma and other respiratory diseases[2].
References	[1]. Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. [2]. Ho PP, et al. Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46(13):917-25.

Boiling Point	440.8ºC at 760mmHg
Molecular Formula	C₁₃H₁₃NaO₄S
Molecular Weight	288.29500
Flash Point	220.4ºC
Exact Mass	288.04300
PSA	86.83000
LogP	2.06220
Vapour Pressure	1.52E-08mmHg at 25°C

tibenelast sodium

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