Tsugafolin

Modify Date: 2025-08-22 09:36:35

Tsugafolin Structure
Tsugafolin structure
Common Name Tsugafolin
CAS Number 66568-97-6 Molecular Weight 300.31
Density 1.3±0.1 g/cm3 Boiling Point 524.4±50.0 °C at 760 mmHg
Molecular Formula C17H16O5 Melting Point N/A
MSDS N/A Flash Point 196.0±23.6 °C

 Use of Tsugafolin


Tsugafolin (compound 4) is a dehydroflavone with weak anti-HIV activity (IC50=118 μM) and devoid cytotoxicity (<150 μM). Tsugafolin can be isolated from Vitex leptobotrys[1].

 Names

Name (3E)-4-(5-Hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-on e
Synonym More Synonyms

 Tsugafolin Biological Activity

Description Tsugafolin (compound 4) is a dehydroflavone with weak anti-HIV activity (IC50=118 μM) and devoid cytotoxicity (<150 μM). Tsugafolin can be isolated from Vitex leptobotrys[1].
Related Catalog
References

[1]. Tanaka R, et al. A new flavanone derivative from the leaves of Tsuga diversifolia[J]. Planta medica, 1989, 55(06): 570-571.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 524.4±50.0 °C at 760 mmHg
Molecular Formula C17H16O5
Molecular Weight 300.31
Flash Point 196.0±23.6 °C
Exact Mass 300.099762
PSA 64.99000
LogP 3.62
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.597
InChIKey KFGFEKHSEPSVNO-UHFFFAOYSA-N
SMILES COc1ccc(C2CC(=O)c3c(OC)cc(O)cc3O2)cc1

 Safety Information

Hazard Codes Xi

 TsugafolinBioassay

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Name: Therapeutic index, ratio of TC50 for MDCK cells to IC50 for Influenza A virus infecte...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1052280
Name: Therapeutic index, ratio of TC50 for human Hep2 cells to IC50 for Parainfluenza virus...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1052278
Name: Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleava...
Source: ChEMBL
Target: Genome polyprotein
External Id: CHEMBL861153
Name: Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleava...
Source: ChEMBL
Target: Genome polyprotein
External Id: CHEMBL861154
Name: Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleava...
Source: ChEMBL
Target: Genome polyprotein
External Id: CHEMBL861155
Name: Cytotoxicity against human HOG.R5 cells infected with HIV-1 3B at 150 uM
Source: ChEMBL
Target: N/A
External Id: CHEMBL3124564
Name: Cytotoxicity against human HOG.R5 cells infected with HIV-1 3B at 148 uM
Source: ChEMBL
Target: N/A
External Id: CHEMBL3124567
Name: Inhibition of dengue2 virus NS2B/NS3 protease activity for Ac-Thr-Arg-Arg-MCA cleavag...
Source: ChEMBL
Target: Genome polyprotein
External Id: CHEMBL861160
Name: Cytotoxicity against human HOG.R5 cells infected with HIV-1 3B assessed as inhibition...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3124568
Name: Inhibition of dengue2 virus NS2B/NS3 protease activity for Ac-Thr-Arg-Arg-MCA cleavag...
Source: ChEMBL
Target: Genome polyprotein
External Id: CHEMBL861161
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 Synonyms

7-Hydroxy-5-methoxy-2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one
Tsugafolin
7-Hydroxy-5,4'-dimethoxyflavanone
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