Doramectin
Doramectin structure
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Common Name | Doramectin | ||
|---|---|---|---|---|
| CAS Number | 117704-25-3 | Molecular Weight | 899.114 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 967.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C50H74O14 | Melting Point | 116 - 119ºC | |
| MSDS | Chinese USA | Flash Point | 274.4±27.8 °C | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
Use of DoramectinDoramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | doramectin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 967.4±65.0 °C at 760 mmHg |
| Melting Point | 116 - 119ºC |
| Molecular Formula | C50H74O14 |
| Molecular Weight | 899.114 |
| Flash Point | 274.4±27.8 °C |
| Exact Mass | 898.507874 |
| PSA | 170.06000 |
| LogP | 7.16 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.580 |
| InChIKey | QLFZZSKTJWDQOS-TTXKVKCHSA-N |
| SMILES | COC1CC(OC2C(C)OC(OC3C(C)=CCC4CC(CC5(C=CC(C)C(C6CCCCC6)O5)O4)OC(=O)C4C=C(C)C(O)C5OCC(=CC=CC3C)C45O)CC2OC)OC(C)C1O |
| Storage condition | 0-6°C |
| Water Solubility | methanol: soluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H410 |
| Precautionary Statements | P273-P301 + P310-P501 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | T,N,Xi |
| Risk Phrases | R25 |
| Safety Phrases | 33-45-60-61-36/37-26 |
| RIDADR | UN 2811 6.1/PG 3 |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Anthelmintic resistance in a herd of alpacas (Vicugna pacos).
Can. Vet. J. 53(12) , 1310-3, (2012) A herd of alpacas was examined because of a history of severe endoparasitism, anemia, hypoproteinemia, and weight loss. Resistance of gastrointestinal nematodes to albendazole, fenbendazole, and doram... |
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Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin.
J. Pharm. Pharmacol. 62(3) , 393-9, (2010) Multidrug resistance (MDR) is a serious obstacle encountered in cancer treatment. This study was performed to explore the reversal of MDR by doramectin from the avermectin family and nemadectin belong... |
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The influence of gastrointestinal parasitism on fecal elimination of doramectin, in lambs.
Ecotoxicol. Environ. Saf. 73(8) , 2017-21, (2010) A study was done to investigate the effect of parasitism on patterns of doramectin (DRM) fecal elimination in lambs. Fourteen Suffolk Down parasitized lambs (26.9 ± 1.5 kg body weight: bw) were purpos... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Doromectin |
| extended von Baeyer nomenclature: (10E,14E,16E)-(1R,4S,5’S,6S,6’R,8R,12S,13S,20R,21R,24S)-6’-cyclohexyl-21,24-dihydroxy-5’,11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2’-(5’,6’-dihydro-2’H-pyran)-12-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside |
| Doramectina |
| Doramectin |
| 25-cyclohexyl-avermectin B1 |
| DONGGUAI.P.E |
| bridged fused ring systems nomenclature: (2aE,4E,8E)-(5’S,6S,6’R,7S,11R,13S,15S,17aR,20R,20aR,20bS)-6’-cyclohexyl-5’,6,6’,7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5’,6,8,19-tetramethyl-17-oxospiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2’-[2H]pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside |
| Dectoma |
| Dectomax |
| 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a |
| Doramecin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of doramectin? |
| A: Polar surface area (PSA) of doramectin is 170.06000. |
| Q: What is the CAS number of doramectin? |
| A: CAS number of doramectin is 117704-25-3. |
| Q: What is the LogP of doramectin? |
| A: LogP of doramectin is 7.16. |
| Q: What is the boiling point of doramectin? |
| A: Boiling point of doramectin is 967.4±65.0 °C at 760 mmHg. |
| Q: How is the water solubility of doramectin? |
| A: Water solubility of doramectin: methanol: soluble. |
| Q: What is the InChIKey of doramectin? |
| A: InChIKey of doramectin is QLFZZSKTJWDQOS-TTXKVKCHSA-N. |
| Q: What is the molecular formula of doramectin? |
| A: Molecular formula of doramectin is C50H74O14. |
| Q: What is the melting point of doramectin? |
| A: Melting point of doramectin is 116 - 119ºC. |
| Q: What are the uses of doramectin? |
| A: Main uses of doramectin: Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins. |
| Q: What is the English name of doramectin? |
| A: The English name of doramectin is doramectin. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |