1-METHYL-3-(2-THIENYL)-1H-PYRAZOL-5-AMINE

Modify Date: 2026-07-12 07:58:51

1-METHYL-3-(2-THIENYL)-1H-PYRAZOL-5-AMINE Structure
1-METHYL-3-(2-THIENYL)-1H-PYRAZOL-5-AMINE structure
Common Name 1-METHYL-3-(2-THIENYL)-1H-PYRAZOL-5-AMINE
CAS Number 118430-78-7 Molecular Weight 179.24200
Density 1.37g/cm3 Boiling Point 370.3ºC at 760mmHg
Molecular Formula C8H9N3S Melting Point 137-140ºC
MSDS USA Flash Point 177.7ºC

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2-methyl-5-thiophen-2-ylpyrazol-3-amine
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.37g/cm3
Boiling Point 370.3ºC at 760mmHg
Melting Point 137-140ºC
Molecular Formula C8H9N3S
Molecular Weight 179.24200
Flash Point 177.7ºC
Exact Mass 179.05200
PSA 72.08000
LogP 2.31200
Vapour Pressure 1.12E-05mmHg at 25°C
Index of Refraction 1.709
InChIKey NFTITKUYTQZKIZ-UHFFFAOYSA-N
SMILES Cn1nc(-c2cccs2)cc1N

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Name: 1-Methyl-3-(2-thienyl)-1H-pyrazol-5-amine 97% Material Safety Data Sheet
Synonym:
CAS: 118430-78-7
Section 1 - Chemical Product MSDS Name:1-Methyl-3-(2-thienyl)-1H-pyrazol-5-amine 97% Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
118430-78-7 1-Methyl-3-(2-thienyl)-1H-pyrazol-5-am 97% unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 118430-78-7: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: beige
Odor: characteristic odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 137 - 140 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H9N3S
Molecular Weight: 179

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 118430-78-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1-Methyl-3-(2-thienyl)-1H-pyrazol-5-amine - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 118430-78-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 118430-78-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 118430-78-7 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xn
Risk Phrases 36/37/38
Safety Phrases 26-36/37/39
HS Code 2934999090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

~59%

1-METHYL-3-(2-THIENYL)-1H-PYRAZOL-5-AMINE Structure

1-METHYL-3-(2-T...

CAS#:118430-78-7

Learn More
Literature: Chemical and Pharmaceutical Bulletin, , vol. 35, # 8 p. 3235 - 3252

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  2

DownStream  0

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Bioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262
Name: Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv...
Source: Shanghai Institute of Organic Chemistry
Target: N/A
External Id: PDBbind-Kd for protein-ligand complexes
Name: Screen for inhibitors of RMI FANCM (MM2) intereaction
Source: 11908
Target: N/A
External Id: RMI-FANCM-MM2
Name: High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS1303
Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
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1

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

1-Methyl-3-(2-Thienyl)-1H-Pyrazol-5-Amine
1H-Pyrazol-5-amine,1-methyl-3-(2-thienyl)
1-Methyl-3-(Thiophen-2-Yl)-1h-Pyrazol-5-Amine
3ovn
5-amino-1-methyl-3-(thien-2-yl)pyrazole
1-methyl-3-(2-thienyl)pyrazole-5-ylamine
5-amino-1-methyl-3-(2-thienyl)pyrazle

  | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: InChIKey of 2-methyl-5-thiophen-2-ylpyrazol-3-amine is NFTITKUYTQZKIZ-UHFFFAOYSA-N.
Q: What is the SMILES notation of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: SMILES notation of 2-methyl-5-thiophen-2-ylpyrazol-3-amine is Cn1nc(-c2cccs2)cc1N.
Q: What is the molecular weight of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: Molecular weight of 2-methyl-5-thiophen-2-ylpyrazol-3-amine is 179.24200.
Q: What is the CAS number of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: CAS number of 2-methyl-5-thiophen-2-ylpyrazol-3-amine is 118430-78-7.
Q: What is the English name of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: The English name of 2-methyl-5-thiophen-2-ylpyrazol-3-amine is 2-methyl-5-thiophen-2-ylpyrazol-3-amine.
Q: What is the boiling point of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: Boiling point of 2-methyl-5-thiophen-2-ylpyrazol-3-amine is 370.3ºC at 760mmHg.
Q: What are the upstream materials of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: Related upstream materials(CAS) of 2-methyl-5-thiophen-2-ylpyrazol-3-amine: 33898-90-7;60-34-4.
Q: What is the safety information for 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: Safety information for 2-methyl-5-thiophen-2-ylpyrazol-3-amine: 26-36/37/39.
Q: What is the molecular formula of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: Molecular formula of 2-methyl-5-thiophen-2-ylpyrazol-3-amine is C8H9N3S.
Q: What is the LogP of 2-methyl-5-thiophen-2-ylpyrazol-3-amine?
A: LogP of 2-methyl-5-thiophen-2-ylpyrazol-3-amine is 2.31200.

 factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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