Tos-PEG2-OH

Modify Date: 2026-08-08 09:40:18

Tos-PEG2-OH structure	Common Name	Tos-PEG2-OH
	CAS Number	118591-58-5	Molecular Weight	260.30700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₆O₅S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Tos-PEG2-OH

Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula	C₁₁H₁₆O₅S
Molecular Weight	260.30700
Exact Mass	260.07200
PSA	81.21000
LogP	1.79000
InChIKey	KLDLLRZCWYKJBD-UHFFFAOYSA-N
SMILES	Cc1ccc(S(=O)(=O)OCCOCCO)cc1

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xn
HS Code	2909499000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Tosyl chloride

CAS#:98-59-9

Diethylene glycol

CAS#:111-46-6

~97%

Tos-PEG2-OH

CAS#:118591-58-5

Learn More

Literature: NATIONAL UNIVERSITY OF IRELAND, GALWAY Patent: US2011/217750 A1, 2011 ; Location in patent: Page/Page column 19 ;

Methyl-PEG2-alcohol

CAS#:111-77-3

Tosyl chloride

CAS#:98-59-9

Tos-PEG2-OH

CAS#:118591-58-5

Learn More

Literature: Song, Rita; Kim, Yeong-Sang; Lee, Chong Ock; Sohn, Youn Soo Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1537 - 1540

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 3
CAS#:98-59-9 Tosyl chloride CAS#:111-46-6 Diethylene glycol CAS#:111-77-3 Methyl-PEG2-alcohol
DownStream 5
CAS#:139115-90-5 Azido-PEG2-alcohol CAS#:312610-28-9 3,4-bis[2-(2-hy... CAS#:142879-00-3 2-[2-(4-phenylm... CAS#:783-88-0 N-[2-(2-hydroxy...
CAS#:72358-83-9 N,N-bis[2-(2-hy...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-(2-hydroxyethoxy)ethyl p-methylbenzenesulfonate

2-(2-hydroxyethoxy)ethyl 4-methyl benzenesulfonate

toluene-4-sulfonic acid 2-(2-hydroxyethoxy)ethyl ester

2-(2-{[(4-methylbenzene)sulfonyl]oxy}ethoxy)ethan-1-ol

diethylene glycol mono-p-toluenesulfonate

Ts(OCH2CH2)2OH

Ethanol,2-(2-hydroxyethoxy)-,1-(4-Methylbenzenesulfonate)

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the uses of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: Main uses of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate: Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Q: What is the English name of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: The English name of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate is 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate.

Q: What are the upstream materials of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: Related upstream materials(CAS) of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate: 98-59-9;111-46-6;111-77-3.

Q: What are the downstream products of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: Related downstream products(CAS) of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate: 139115-90-5;312610-28-9;142879-00-3;783-88-0;72358-83-9.

Q: What is the LogP of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: LogP of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate is 1.79000.

Q: What is the SMILES notation of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: SMILES notation of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate is Cc1ccc(S(=O)(=O)OCCOCCO)cc1.

Q: What is the InChIKey of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: InChIKey of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate is KLDLLRZCWYKJBD-UHFFFAOYSA-N.

Q: What is the CAS number of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: CAS number of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate is 118591-58-5.

Q: What English synonyms does 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate have?

A: English synonyms of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate: 2-(2-hydroxyethoxy)ethyl p-methylbenzenesulfonate, 2-(2-hydroxyethoxy)ethyl 4-methyl benzenesulfonate, toluene-4-sulfonic acid 2-(2-hydroxyethoxy)ethyl ester, 2-(2-{[(4-methylbenzene)sulfonyl]oxy}ethoxy)ethan-1-ol, diethylene glycol mono-p-toluenesulfonate, Ts(OCH2CH2)2OH, Ethanol,2-(2-hydroxyethoxy)-,1-(4-Methylbenzenesulfonate).

Q: What is the molecular formula of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate?

A: Molecular formula of 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate is C11H16O5S.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tos-PEG2-OH
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.