Sennoside B
Sennoside B structure
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Common Name | Sennoside B | ||
|---|---|---|---|---|
| CAS Number | 128-57-4 | Molecular Weight | 862.739 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 1144.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C42H38O20 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 348.6±27.8 °C | |
Use of Sennoside BSennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | sennoside B |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway[2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 1144.8±65.0 °C at 760 mmHg |
| Molecular Formula | C42H38O20 |
| Molecular Weight | 862.739 |
| Flash Point | 348.6±27.8 °C |
| Exact Mass | 862.195618 |
| PSA | 347.96000 |
| LogP | 1.88 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.763 |
| InChIKey | IPQVTOJGNYVQEO-AIFLABODSA-N |
| SMILES | O=C(O)c1cc(O)c2c(c1)C(C1c3cc(C(=O)O)cc(O)c3C(=O)c3c(OC4OC(CO)C(O)C(O)C4O)cccc31)c1cccc(OC3OC(CO)C(O)C(O)C3O)c1C2=O |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R22 |
| Safety Phrases | 22-45 |
| RIDADR | NONH for all modes of transport |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:517-44-2
CAS#:82334-26-7This table lists relevant public references with title, journal and publication metadata for this compound.
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The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice.
Biol. Pharm. Bull. 35(12) , 2204-8, (2012) Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. Sennoside A is transformed into an active metabolite, rheinant... |
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The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice.
Biol. Pharm. Bull. 34(9) , 1438-42, (2011) Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influe... |
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Effects of optimized-SopungSunkiwon on memory impairment and enhancement.
Neurosci. Lett. 491(2) , 93-8, (2011) Optimized-SopungSunkiwon (OSS) is a multi-herbal formula that contains six medicinal herbs from SopungSunkiwon, a traditional medicine used for neurodegenerative disorders. In this study, we investiga... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| SennosideB |
| Sennoside B |
| EINECS 204-895-0 |
| MFCD00151528 |
| (9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid |
| (9R,9'S)-4,4'-Dihydroxy-10,10'-dioxo-5,5'-bis{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of sennoside B? |
| A: Molecular weight of sennoside B is 862.739. |
| Q: What is the SMILES notation of sennoside B? |
| A: SMILES notation of sennoside B is O=C(O)c1cc(O)c2c(c1)C(C1c3cc(C(=O)O)cc(O)c3C(=O)c3c(OC4OC(CO)C(O)C(O)C4O)cccc31)c1cccc(OC3OC(CO)C(O)C(O)C3O)c1C2=O. |
| Q: What is the polar surface area (PSA) of sennoside B? |
| A: Polar surface area (PSA) of sennoside B is 347.96000. |
| Q: What is the CAS number of sennoside B? |
| A: CAS number of sennoside B is 128-57-4. |
| Q: What is the English name of sennoside B? |
| A: The English name of sennoside B is sennoside B. |
| Q: What is the LogP of sennoside B? |
| A: LogP of sennoside B is 1.88. |
| Q: What is the molecular formula of sennoside B? |
| A: Molecular formula of sennoside B is C42H38O20. |
| Q: What are the downstream products of sennoside B? |
| A: Related downstream products(CAS) of sennoside B: 517-44-2;82334-26-7. |
| Q: What is the safety information for sennoside B? |
| A: Safety information for sennoside B: 22-45. |
| Q: What is the boiling point of sennoside B? |
| A: Boiling point of sennoside B is 1144.8±65.0 °C at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |