Levosimendan
Levosimendan structure
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Common Name | Levosimendan | ||
|---|---|---|---|---|
| CAS Number | 141505-33-1 | Molecular Weight | 280.285 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H12N6O | Melting Point | 216-219ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of LevosimendanLevosimendan(OR1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.Target: OthersLevosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. Levosimendan is an inodilator indicated for the short-term treatment of acutely decompensated severe chronic heart failure, and in situations where conventional therapy is not considered adequate. Levosimendan has shown preliminary positive effects in a range of conditions requiring inotropic support, including right ventricular failure, cardiogenic shock, septic shock, and Takotsubo cardiomyopathy [1]. The cardiovascular effects of levosimendan are exerted via more than an isolated drug-receptor interaction, and involve favorable energetic and neurohormonal changes that are unique in comparison to other types of inodilators [2]. Levosimendan might reduce mortality in cardiac surgery and cardiology settings of adult patients [3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | levosimendan |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Levosimendan(OR1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.Target: OthersLevosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. Levosimendan is an inodilator indicated for the short-term treatment of acutely decompensated severe chronic heart failure, and in situations where conventional therapy is not considered adequate. Levosimendan has shown preliminary positive effects in a range of conditions requiring inotropic support, including right ventricular failure, cardiogenic shock, septic shock, and Takotsubo cardiomyopathy [1]. The cardiovascular effects of levosimendan are exerted via more than an isolated drug-receptor interaction, and involve favorable energetic and neurohormonal changes that are unique in comparison to other types of inodilators [2]. Levosimendan might reduce mortality in cardiac surgery and cardiology settings of adult patients [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Melting Point | 216-219ºC (dec.) |
| Molecular Formula | C14H12N6O |
| Molecular Weight | 280.285 |
| Exact Mass | 280.107269 |
| PSA | 113.43000 |
| LogP | 0.59 |
| Index of Refraction | 1.673 |
| InChIKey | WHXMKTBCFHIYNQ-SECBINFHSA-N |
| SMILES | CC1CC(=O)NN=C1c1ccc(NN=C(C#N)C#N)cc1 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Hazard Codes | Xn |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S36/S37 |
| RIDADR | NONH for all modes of transport |
| RTECS | TY1570210 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Levosimendan CAS#:141505-33-1 |
| Literature: WO2011/7123 A1, ; Page/Page column 11-12 ; |
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Levosimendan CAS#:141505-33-1 |
| Literature: WO2011/7123 A1, ; |
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Levosimendan CAS#:141505-33-1 |
| Literature: WO2011/7123 A1, ; |
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Levosimendan CAS#:141505-33-1 |
| Literature: WO2011/7123 A1, ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
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| DownStream 0 | |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Levosimendan exerts anti-inflammatory effects on cardiac myocytes and endothelial cells in vitro.
Thromb. Haemost. 113(2) , 350-62, (2015) Levosimendan is a positive inotropic drug for the treatment of acute decompensated heart failure (HF). Clinical trials showed that levosimendan was particularly effective in HF due to myocardial infar... |
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Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.
Skelet. Muscle 5 , 12, (2015) Nemaline myopathy (NM), the most common non-dystrophic congenital myopathy, is characterized by generalized skeletal muscle weakness, often from birth. To date, no therapy exists that enhances the con... |
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A Bayesian network meta-analysis on the effect of inodilatory agents on mortality.
Br. J. Anaesth. 114 , 746-56, (2015) Inodilators are commonly used in critically ill patients, but their effect on survival has not been properly studied to date. The objective of this work was to conduct a network meta-analysis on the e... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Levosimedan |
| Mesoxalonitrile (-)-[p-[(R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazone |
| ({4-[(4R)-4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl]phenyl}hydrazono)malononitrile |
| ({4-[(4R)-4-Methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridazinyl]phenyl}hydrazono)malononitrile |
| (R)-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile |
| Levosimendan |
| (R)-(-)-2-[4-(4-methyl-6-oxo-1,4,5,6,-tetrahydropyridazin-3-yl)phenylhydrazono]propanedinitrile |
| MFCD00867135 |
| Simdax |
| (2-{4-[(4R)-4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl]phenyl}hydrazinyliden)propandinitril |
| 2-[[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]hydrazinylidene]propanedinitrile |
| (R)-Simendan |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of levosimendan? |
| A: LogP of levosimendan is 0.59. |
| Q: What is the polar surface area (PSA) of levosimendan? |
| A: Polar surface area (PSA) of levosimendan is 113.43000. |
| Q: What is the safety information for levosimendan? |
| A: Safety information for levosimendan: S36/S37. |
| Q: What is the CAS number of levosimendan? |
| A: CAS number of levosimendan is 141505-33-1. |
| Q: What is the SMILES notation of levosimendan? |
| A: SMILES notation of levosimendan is CC1CC(=O)NN=C1c1ccc(NN=C(C#N)C#N)cc1. |
| Q: What is the English name of levosimendan? |
| A: The English name of levosimendan is levosimendan. |
| Q: What is the InChIKey of levosimendan? |
| A: InChIKey of levosimendan is WHXMKTBCFHIYNQ-SECBINFHSA-N. |
| Q: What are the upstream materials of levosimendan? |
| A: Related upstream materials(CAS) of levosimendan: 36725-28-7;109-77-3;101328-84-1;1260774-44-4. |
| Q: What is the molecular formula of levosimendan? |
| A: Molecular formula of levosimendan is C14H12N6O. |
| Q: What is the melting point of levosimendan? |
| A: Melting point of levosimendan is 216-219ºC (dec.). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |