Retigabine
Retigabine structure
|
Common Name | Retigabine | ||
|---|---|---|---|---|
| CAS Number | 150812-12-7 | Molecular Weight | 303.331 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 430.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H18FN3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 213.9±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of RetigabineRetigabine is a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | ezogabine |
|---|---|
| Synonym | More Synonyms |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 430.0±45.0 °C at 760 mmHg |
| Molecular Formula | C16H18FN3O2 |
| Molecular Weight | 303.331 |
| Flash Point | 213.9±28.7 °C |
| Exact Mass | 303.138306 |
| PSA | 76.38000 |
| LogP | 0.81 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.656 |
| InChIKey | PCOBBVZJEWWZFR-UHFFFAOYSA-N |
| SMILES | CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N |
| Storage condition | room temp |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H413 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | T,N,Xn,F,Xi |
| Risk Phrases | 23-25-50/53-36-20/21/22-11 |
| Safety Phrases | 45-60-61-36/37-16-26 |
| RIDADR | NONH for all modes of transport |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists relevant public references with title, journal and publication metadata for this compound.
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Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.
Epilepsia 55(4) , 601-8, (2014) A NaV β1(C121W) mouse model of human genetic epilepsy has enhanced neuronal excitability and temperature sensitivity attributed to a decreased threshold for action potential firing in the axon initial... |
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Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel.
Expert Opin. Drug Saf. 12(6) , 847-55, (2013) Complex-partial seizures are frequently resistant to antiepileptic therapy. Two new medications with mechanisms of action novel within the antiepileptic class have recently received approval for the a... |
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Ezogabine (retigabine) and its role in the treatment of partial-onset seizures: a review.
Clin. Ther. 34(9) , 1845-56.e1, (2012) Ezogabine, also known as retigabine, is a recently approved anticonvulsant medication with a novel mechanism of action. It activates low-threshold voltage-gated potassium channels, leading to hyperpol... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethylester |
| Retigabine |
| Carbamic acid, N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-, ethyl ester |
| Trobalt |
| [2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester |
| 2-Amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzene |
| N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester |
| Ethyl (2-amino-4-(((4-fluorophenyl)methyl)amino)phenyl)carbamate |
| Ezogabine |
| D-23129, Ezogabine, N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester |
| Ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate |
| Potiga |
| EINECS 200-835-2 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the safety information for ezogabine? |
| A: Safety information for ezogabine: 45-60-61-36/37-16-26. |
| Q: What is the English name of ezogabine? |
| A: The English name of ezogabine is ezogabine. |
| Q: What is the InChIKey of ezogabine? |
| A: InChIKey of ezogabine is PCOBBVZJEWWZFR-UHFFFAOYSA-N. |
| Q: What are the storage conditions for ezogabine? |
| A: Storage conditions for ezogabine: room temp. |
| Q: What is the polar surface area (PSA) of ezogabine? |
| A: Polar surface area (PSA) of ezogabine is 76.38000. |
| Q: What is the SMILES notation of ezogabine? |
| A: SMILES notation of ezogabine is CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N. |
| Q: What is the LogP of ezogabine? |
| A: LogP of ezogabine is 0.81. |
| Q: What is the CAS number of ezogabine? |
| A: CAS number of ezogabine is 150812-12-7. |
| Q: What are the uses of ezogabine? |
| A: Main uses of ezogabine: Retigabine is a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. |
| Q: What is the molecular weight of ezogabine? |
| A: Molecular weight of ezogabine is 303.331. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |