2'-C-Methyladenosine

Modify Date: 2026-07-01 21:20:20

2'-C-Methyladenosine structure	Common Name	2'-C-Methyladenosine
	CAS Number	15397-12-3	Molecular Weight	281.268
	Density	1.9±0.1 g/cm3	Boiling Point	643.4±65.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₅N₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	342.9±34.3 °C

Use of 2'-C-Methyladenosine

2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	IC50: 0.3μM (HCV replicon); 1.9 μM (NS5B)[1]
In Vivo	2'-C-Methyladenosine has inhibitory potency for HCV replicon in HB110A cells with an IC50 values of 0.3μM[1]. 2'-C-Methyladenosine inhibits NS5B-catalyzed RNA synthesis with an IC50 values of 1.9 μM[1]. 2′-C-methyladenosine potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[2]

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.9±0.1 g/cm3
Boiling Point	643.4±65.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₅N₅O₄
Molecular Weight	281.268
Flash Point	342.9±34.3 °C
Exact Mass	281.112396
PSA	139.54000
LogP	0.55
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.823
InChIKey	PASOFFRBGIVJET-YRKGHMEHSA-N
SMILES	CC1(O)C(O)C(CO)OC1n1cnc2c(N)ncnc21

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovi...
Source: ChEMBL
Target: Adenosine receptor A1
External Id: CHEMBL637553

Name: Cytotoxicity against human A549 cells assessed as intracellular ATP level by Celltite...
Source: ChEMBL
Target: A549
External Id: CHEMBL1637304

Name: Antiviral activity against at 0.3 MOI Dengue virus 2 infected in human A549 cells ass...
Source: ChEMBL
Target: dengue virus type 2
External Id: CHEMBL1637305

Name: Inhibitory activity at Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 bindin...
Source: ChEMBL
Target: Adenosine receptor A2a
External Id: CHEMBL873042

Name: Cytotoxic concentration required to reduce the rRNA level of hepatitis C virus
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL883168

Name: Cytotoxicity against Huh7 cells by MTS assay
Source: ChEMBL
Target: Huh-7
External Id: CHEMBL867727

Name: Antiviral activity against HCV replication
Source: ChEMBL
Target: Hepacivirus hominis
External Id: CHEMBL867726

Name: Cytotoxicity against Huh7 cells after 24 hrs by MTS assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL898200

Name: Antiviral activity against BVDV NADL in MDBK cells
Source: ChEMBL
Target: Bovine viral diarrhea virus 1
External Id: CHEMBL863835

Name: Cytotoxicity against MDBK cells
Source: ChEMBL
Target: MDBK441
External Id: CHEMBL863836

Total 86, Current Page 1 of 9

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2'-C-Methyladenosine

2-(6-amino-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydrofuran-3,4-diol

2'-METHYLADENOSINE

2'-C-methyl adenosine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: Polar surface area (PSA) of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is 139.54000.

Q: What is the LogP of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: LogP of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is 0.55.

Q: What is the boiling point of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: Boiling point of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is 643.4±65.0 °C at 760 mmHg.

Q: What is the CAS number of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: CAS number of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is 15397-12-3.

Q: What is the molecular weight of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: Molecular weight of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is 281.268.

Q: What are the uses of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: Main uses of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol: 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].

Q: What is the SMILES notation of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: SMILES notation of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is CC1(O)C(O)C(CO)OC1n1cnc2c(N)ncnc21.

Q: What is the molecular formula of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: Molecular formula of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is C11H15N5O4.

Q: What is the InChIKey of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol?

A: InChIKey of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is PASOFFRBGIVJET-YRKGHMEHSA-N.

Q: What English synonyms does (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol have?

A: English synonyms of (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol: 2'-C-Methyladenosine, 2-(6-amino-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydrofuran-3,4-diol, 2'-METHYLADENOSINE, 2'-C-methyl adenosine.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2'-C-Methyladenosine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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2'-C-Methyladenosine

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.