2'-C-Methyladenosine

Names

[ Name ]:
2'-C-Methyladenosine

[Synonym ]:
2'-C-Methyladenosine
2-(6-amino-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydrofuran-3,4-diol
2'-METHYLADENOSINE
2'-C-methyl adenosine
Adenosine, 2'-C-methyl-

Biological Activity

[Description]:

2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.3μM (HCV replicon); 1.9 μM (NS5B)[1]

[In Vivo]

2'-C-Methyladenosine has inhibitory potency for HCV replicon in HB110A cells with an IC50 values of 0.3μM[1]. 2'-C-Methyladenosine inhibits NS5B-catalyzed RNA synthesis with an IC50 values of 1.9 μM[1]. 2′-C-methyladenosine potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[2]

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
643.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₅N₅O₄

[ Molecular Weight ]:
281.268

[ Flash Point ]:
342.9±34.3 °C

[ Exact Mass ]:
281.112396

[ PSA ]:
139.54000

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.823

Related Compounds

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