Adelmidrol
Adelmidrol structure
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Common Name | Adelmidrol | ||
|---|---|---|---|---|
| CAS Number | 1675-66-7 | Molecular Weight | 274.35700 | |
| Density | 1.097g/cm3 | Boiling Point | 596.4ºC at 760mmHg | |
| Molecular Formula | C13H26N2O4 | Melting Point | 132-134 ºC | |
| MSDS | N/A | Flash Point | 314.5ºC | |
Use of AdelmidrolAdelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and COX-2 expression. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | N,N'-bis(2-hydroxyethyl)nonanediamide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and COX-2 expression. |
|---|---|
| Related Catalog | |
| Target |
NF-κB COX-2 PPARγ |
| In Vitro | Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation, COX-2, and p-ERK expression; proinflammatory cytokine release; and the incidence of nitrotyrosine and poly(ADP)ribose in the colon[1]. |
| In Vivo | Adelmidrol (10 mg/kg, o.s.) reduces significantly the degree and severity of the macroscopic and histologic signs of colon injury. Moreover, 4 days after colitis induced by dinitrobenzene sulfonic acid (DNBS) treatment, all mice have diarrhea and a reduction in body weight (compared with the sham groups). Adelmidrol (10 mg/kg, o.s.) treatment significantly reduces the loss of body weight. The inflammatory bowel disease (IBD) induced by DNBS intrarectally administered is also characterized by an augmentation in myeloperoxidase (MPO) activity, an indicator of neutrophil accumulating in the colon. This is consistent with light microscopic observations showing the colon of vehicle-treated DNBS mice to contain a large number of neutrophils. In contrast, Adelmidrol (10 mg/kg, o.s.) significantly reduces the degree of polymorphonuclear cell infiltration (determined as reduction in MPO activity) in inflamed colon[1]. |
| Animal Admin | Mice[1] Male adult CD1 mice (25-30 g) and male mice (20-27 g) are placed in a controlled environment and maintained on a 12-hour light/dark cycle with food and water available ad libitum. Mice are casually divided into the following groups (10 in each group) (1)Sham+vehicle group: Vehicle solution (saline) is given by oral administration for 4 days. (2) Sham+Adelmidrol (10 mg/kg): Administered o.s. for 4 days. (3) DNBS+vehicle: Mice are injected by DNBS as described, and vehicle (saline) is given o.s. each day for 4 days, starting 60 minutes after the injection of DNBS. (4) DNBS+Adelmidrol (10 mg/kg): Mice are injected by DNBS as described, and Adelmidrol (10 mg/kg) is given o.s. each day, starting 60 minutes after administration of DNBS[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.097g/cm3 |
|---|---|
| Boiling Point | 596.4ºC at 760mmHg |
| Melting Point | 132-134 ºC |
| Molecular Formula | C13H26N2O4 |
| Molecular Weight | 274.35700 |
| Flash Point | 314.5ºC |
| Exact Mass | 274.18900 |
| PSA | 98.66000 |
| LogP | 0.71590 |
| Vapour Pressure | 1.04E-16mmHg at 25°C |
| Index of Refraction | 1.492 |
| InChIKey | PAHZPHDAJQIETD-UHFFFAOYSA-N |
| SMILES | O=C(CCCCCCCC(=O)NCCO)NCCO |
| Storage condition | 2-8℃ |
| Water Solubility | Soluble (60 g/L) (25 ºC) |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~77%
Adelmidrol CAS#:1675-66-7 |
| Literature: LIFEGROUP S.p.A. Patent: EP550008 A2, 1993 ; |
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~80%
Adelmidrol CAS#:1675-66-7 |
| Literature: Lifegroup S.P.A. Patent: US5925678 A1, 1999 ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 3 | |
|---|---|
| DownStream 0 | |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: ULK1_INH_LUMI_1536_1X%INH PRUN
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Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149
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Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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Name: Phenotypic Assay to Identify Small Molecules that Upregulate Production of hCFTR in H...
Source: Southern Research Institute
Target: CFTR
External Id: CF Folding
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Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Adelmidrol |
| UNII-1BUC3685QU |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: How is the water solubility of N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: Water solubility of N,N'-bis(2-hydroxyethyl)nonanediamide: Soluble (60 g/L) (25 ºC). |
| Q: What are the storage conditions for N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: Storage conditions for N,N'-bis(2-hydroxyethyl)nonanediamide: 2-8℃. |
| Q: What is the CAS number of N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: CAS number of N,N'-bis(2-hydroxyethyl)nonanediamide is 1675-66-7. |
| Q: What is the InChIKey of N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: InChIKey of N,N'-bis(2-hydroxyethyl)nonanediamide is PAHZPHDAJQIETD-UHFFFAOYSA-N. |
| Q: What is the polar surface area (PSA) of N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: Polar surface area (PSA) of N,N'-bis(2-hydroxyethyl)nonanediamide is 98.66000. |
| Q: What is the molecular formula of N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: Molecular formula of N,N'-bis(2-hydroxyethyl)nonanediamide is C13H26N2O4. |
| Q: What is the LogP of N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: LogP of N,N'-bis(2-hydroxyethyl)nonanediamide is 0.71590. |
| Q: What English synonyms does N,N'-bis(2-hydroxyethyl)nonanediamide have? |
| A: English synonyms of N,N'-bis(2-hydroxyethyl)nonanediamide: Adelmidrol, UNII-1BUC3685QU. |
| Q: What are the uses of N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: Main uses of N,N'-bis(2-hydroxyethyl)nonanediamide: Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and COX-2 expression. |
| Q: What are the upstream materials of N,N'-bis(2-hydroxyethyl)nonanediamide? |
| A: Related upstream materials(CAS) of N,N'-bis(2-hydroxyethyl)nonanediamide: 123-99-9;141-43-5;79-10-7. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |