SDMA
SDMA structure
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Common Name | SDMA | ||
|---|---|---|---|---|
| CAS Number | 30344-00-4 | Molecular Weight | 202.25400 | |
| Density | 1.22g/cm3 | Boiling Point | 367.7ºC at 760mmHg | |
| Molecular Formula | C8H18N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 176.2ºC | |
Use of SDMASDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Nω,N'ω-dimethyl-L-arginine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | SDMA is the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function. SDMA does not directly inhibit NOS but is a competitor of arginine transport. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate[1]. SDMA inhibits dose dependently the NO synthesis in intact endothelial cells, whereas it has no effect on protein expression of NOS[1]. SDMA is involved in the inflammatory process of chronic kidney disease, activating NF-κB and resulting in enhanced expression of IL-6 and TNF-α[2]. |
| In Vivo | SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged whereas in affected dogs, SDMA increases during disease progression, correlating strongly with an increase in sCr and decrease in GFR[3]. Chronic SDMA infusion leads to a significant increase of SDMA levels in mice, but the GFR did not change at 4 weeks. No histological changes are observed, particularly no effect on fibrosis or endothelias nitric oxide synthase expression. There is neither an effect of SDMA on systolic blood pressure nor on ejection fraction[4]. |
| Cell Assay | SDMA stock solution is prepared in 0.9% NaCl and diluted in the cell culture medium or in heparinized whole blood resulting in a maximal uremic concentration of 6.1 μM SDMA. Whole blood is incubated with saline (control) or different doses of ADMA (0.6, 3.6, and 36 μM) or SDMA (1.5, 3.1, and 6.1 μM) for 2 hours in a humidified atmosphere of 5% CO2 in air at 37°C. Cells are finally stained for intracellular TNF-α or IL-6. Samples are analyzed with a flow cytometer[2]. |
| Animal Admin | Mice: Eight-week-old male C57Bl/6 mice receives vehicle-controlled infusion of SDMA (250 µmol/kg/days) for 28 days using osmotic minipumps (n=24/group). Glomerular filtration rate, cardiac function and blood pressure are monitored. Blood samples for SDMA determination are obtained at baseline, 2 and 4 weeks. Mice are euthanized at 4 weeks to obtain tissue for renal histology[4]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.22g/cm3 |
|---|---|
| Boiling Point | 367.7ºC at 760mmHg |
| Molecular Formula | C8H18N4O2 |
| Molecular Weight | 202.25400 |
| Flash Point | 176.2ºC |
| Exact Mass | 202.14300 |
| PSA | 99.74000 |
| LogP | 0.45540 |
| Index of Refraction | 1.54 |
| InChIKey | HVPFXCBJHIIJGS-LURJTMIESA-N |
| SMILES | CN=C(NC)NCCCC(N)C(=O)O |
| Storage condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Stability | Very Hygroscopic |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2925290090 |
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This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2925290090 |
|---|---|
| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| N(omega),N'(omega)-dimethyl-L-arginine |
| NG,NG’-Dimethy-L-arginine-d6 |
| NG,NG′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt |
| SDMA |
| (2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid |
| L-Arg(Me, Me)-OH (symmetrical) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of Nω,N'ω-dimethyl-L-arginine? |
| A: Molecular weight of Nω,N'ω-dimethyl-L-arginine is 202.25400. |
| Q: What are the uses of Nω,N'ω-dimethyl-L-arginine? |
| A: Main uses of Nω,N'ω-dimethyl-L-arginine: SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. |
| Q: What English synonyms does Nω,N'ω-dimethyl-L-arginine have? |
| A: English synonyms of Nω,N'ω-dimethyl-L-arginine: N(omega),N'(omega)-dimethyl-L-arginine, NG,NG’-Dimethy-L-arginine-d6, NG,NG′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt, SDMA, (2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid, L-Arg(Me, Me)-OH (symmetrical). |
| Q: What is the SMILES notation of Nω,N'ω-dimethyl-L-arginine? |
| A: SMILES notation of Nω,N'ω-dimethyl-L-arginine is CN=C(NC)NCCCC(N)C(=O)O. |
| Q: What is the molecular formula of Nω,N'ω-dimethyl-L-arginine? |
| A: Molecular formula of Nω,N'ω-dimethyl-L-arginine is C8H18N4O2. |
| Q: What is the InChIKey of Nω,N'ω-dimethyl-L-arginine? |
| A: InChIKey of Nω,N'ω-dimethyl-L-arginine is HVPFXCBJHIIJGS-LURJTMIESA-N. |
| Q: What is the LogP of Nω,N'ω-dimethyl-L-arginine? |
| A: LogP of Nω,N'ω-dimethyl-L-arginine is 0.45540. |
| Q: What is the English name of Nω,N'ω-dimethyl-L-arginine? |
| A: The English name of Nω,N'ω-dimethyl-L-arginine is Nω,N'ω-dimethyl-L-arginine. |
| Q: What is the boiling point of Nω,N'ω-dimethyl-L-arginine? |
| A: Boiling point of Nω,N'ω-dimethyl-L-arginine is 367.7ºC at 760mmHg. |
| Q: What is the polar surface area (PSA) of Nω,N'ω-dimethyl-L-arginine? |
| A: Polar surface area (PSA) of Nω,N'ω-dimethyl-L-arginine is 99.74000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |