Aclidinium bromide
Aclidinium bromide structure
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Common Name | Aclidinium bromide | ||
|---|---|---|---|---|
| CAS Number | 320345-99-1 | Molecular Weight | 564.555 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H30BrNO4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Aclidinium bromideAclidinium Bromide(LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (COPD). IC50 value:Target: M3 receptorPreclinically, aclidinium showed potent antagonism of human muscarinic receptors, with a long residence time at M3 receptors and a shorter residence time at M2 receptors, indicating the potential to provide sustained bronchodilation. Aclidinium is rapidly hydrolysed in human plasma, unlike other currently available antimuscarinics including tiotropium. Early clinical studies in healthy subjects have confirmed the low systemic bioavailability and favourable safety profile of single and multiple doses of aclidinium. In a subsequent Phase IIb study, which included 464 patients with moderate to severe COPD, aclidinium displayed long-lasting bronchodilatory activity and was well tolerated. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | aclidinium bromide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Aclidinium Bromide(LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (COPD). IC50 value:Target: M3 receptorPreclinically, aclidinium showed potent antagonism of human muscarinic receptors, with a long residence time at M3 receptors and a shorter residence time at M2 receptors, indicating the potential to provide sustained bronchodilation. Aclidinium is rapidly hydrolysed in human plasma, unlike other currently available antimuscarinics including tiotropium. Early clinical studies in healthy subjects have confirmed the low systemic bioavailability and favourable safety profile of single and multiple doses of aclidinium. In a subsequent Phase IIb study, which included 464 patients with moderate to severe COPD, aclidinium displayed long-lasting bronchodilatory activity and was well tolerated. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C26H30BrNO4S2 |
|---|---|
| Molecular Weight | 564.555 |
| Exact Mass | 563.079956 |
| PSA | 112.24000 |
| LogP | 1.62960 |
| InChIKey | XLAKJQPTOJHYDR-QTQXQZBYSA-M |
| SMILES | O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1.[Br-] |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| [(3R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate,bromide |
| UNII-UQW7UF9N91 |
| 1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, bromide, (3R)- (1:1) |
| Tudorza Pressair |
| LAS W-330 |
| (3R)-3-[2-Hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide |
| Eklira |
| Bretaris |
| Aclidinium bromide |
| (3R)-3-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium bromide |
| Aclidinium (Bromide) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of aclidinium bromide? |
| A: Molecular formula of aclidinium bromide is C26H30BrNO4S2. |
| Q: What is the LogP of aclidinium bromide? |
| A: LogP of aclidinium bromide is 1.62960. |
| Q: What is the CAS number of aclidinium bromide? |
| A: CAS number of aclidinium bromide is 320345-99-1. |
| Q: What is the InChIKey of aclidinium bromide? |
| A: InChIKey of aclidinium bromide is XLAKJQPTOJHYDR-QTQXQZBYSA-M. |
| Q: What is the English name of aclidinium bromide? |
| A: The English name of aclidinium bromide is aclidinium bromide. |
| Q: What is the molecular weight of aclidinium bromide? |
| A: Molecular weight of aclidinium bromide is 564.555. |
| Q: What is the polar surface area (PSA) of aclidinium bromide? |
| A: Polar surface area (PSA) of aclidinium bromide is 112.24000. |
| Q: What is the SMILES notation of aclidinium bromide? |
| A: SMILES notation of aclidinium bromide is O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1.[Br-]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |