VGX-1027(Git-27)

Modify Date: 2026-07-01 19:32:53

VGX-1027(Git-27) structure	Common Name	VGX-1027(Git-27)
	CAS Number	6501-72-0	Molecular Weight	205.210
	Density	1.3±0.1 g/cm3	Boiling Point	381.4±34.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₁NO₃	Melting Point	159 °C
	MSDS	N/A	Flash Point	184.5±25.7 °C

Use of VGX-1027(Git-27)

VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.IC50 value: Target: immunomodulatorAdministration of VGX-1027 to NOD mice with spontaneous or accelerated forms of diabetes induced either by injection of cyclophosphamide or by transfer of spleen cells from acutely diabetic syngeneic donors markedly reduced the cumulative incidence of diabetes and insulitis. In addition, VGX-1027 given either i.p. or p.o. to CBA/H mice made diabetic with multiple low doses of streptozotocin successfully counteracted the development of destructive insulitis and hyperglycemia [1]. VGX-1027 appeared to spare T cell function as it was unable to modify the proliferation and/or secretion of IL-2, IFN-gamma and IL-4 induced in purified murine CD4+ T cells from stimulation with either CD3+CD28 or ConA [2]. VGX-1027 inhibited both proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro and the development of clinical and histological signs of colitis in vivo [3].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	VGX-1027(GIT27) is an isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from purified murine macrophages.IC50 value: Target: immunomodulatorAdministration of VGX-1027 to NOD mice with spontaneous or accelerated forms of diabetes induced either by injection of cyclophosphamide or by transfer of spleen cells from acutely diabetic syngeneic donors markedly reduced the cumulative incidence of diabetes and insulitis. In addition, VGX-1027 given either i.p. or p.o. to CBA/H mice made diabetic with multiple low doses of streptozotocin successfully counteracted the development of destructive insulitis and hyperglycemia [1]. VGX-1027 appeared to spare T cell function as it was unable to modify the proliferation and/or secretion of IL-2, IFN-gamma and IL-4 induced in purified murine CD4+ T cells from stimulation with either CD3+CD28 or ConA [2]. VGX-1027 inhibited both proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro and the development of clinical and histological signs of colitis in vivo [3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
References	[1]. Stosic-Grujicic S, et al. A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multipl [2]. Stojanovic I, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immuno [3]. Mangano K, et al. In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027. Eur J Pharmacol. 2008 May 31;586(1-3):313-21.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

References

[1]. Stosic-Grujicic S, et al. A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multipl

[2]. Stojanovic I, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immuno

[3]. Mangano K, et al. In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027. Eur J Pharmacol. 2008 May 31;586(1-3):313-21.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	381.4±34.0 °C at 760 mmHg
Melting Point	159 °C
Molecular Formula	C₁₁H₁₁NO₃
Molecular Weight	205.210
Flash Point	184.5±25.7 °C
Exact Mass	205.073898
PSA	58.89000
LogP	1.16
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.601
InChIKey	MUFJHYRCIHHATF-UHFFFAOYSA-N
SMILES	O=C(O)CC1CC(c2ccccc2)=NO1

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

N-(chloro(pheny...

CAS#:1378834-78-6

3-Butenoic acid

CAS#:625-38-7

VGX-1027(Git-27)

CAS#:6501-72-0

Learn More

Literature: GANIAL IMMUNOTHERAPEUTICS INC. Patent: WO2006/97273 A1, 2006 ; Location in patent: Page/Page column 13 ;

Acetophenone oxime

CAS#:613-91-2

VGX-1027(Git-27)

CAS#:6501-72-0

Learn More

Literature: Eichinger, Karl; Wokurek, Michael; Zauner, Bernd; Rostami, Mohammad Reza Synthetic Communications, 1997 , vol. 27, # 16 p. 2733 - 2742

3-Butenoic acid

CAS#:625-38-7

Alpha-Chloroben...

CAS#:698-16-8

VGX-1027(Git-27)

CAS#:6501-72-0

Learn More

Literature: Stosic-Grujicic, Stanislava; Cvetkovic, Ivana; Mangano, Katia; Fresta, Massimo; Maksimovic-Ivanic, Danijela; Harhaji, Ljubica; Popadic, Dusan; Momcilovic, Miljana; Miljkovic, Djordje; Kim, Joseph; Al Abed, Yousef; Nicoletti, Ferdinando Journal of Pharmacology and Experimental Therapeutics, 2007 , vol. 320, # 3 p. 1038 - 1049

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 3
CAS#:625-38-7 3-Butenoic acid CAS#:613-91-2 Acetophenone oxime CAS#:698-16-8 Alpha-Chloroben...
DownStream 0

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2
Source: NCGC
Target: eyes absent homolog 2 isoform a [Homo sapiens]
External Id: EYA2477

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2...
Source: NCGC
Target: ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens]
External Id: UBCH001

Name: qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus...
Source: NCGC
Target: N/A
External Id: ZIK159

Name: qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay
Source: NCGC
Target: arylsulfatase A [Homo sapiens]
External Id: asa1-v2

Name: qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t...
Source: NCGC
Target: N/A
External Id: MCC011

Name: Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit...
Source: NCGC
External Id: CIB1-p1-p2

Name: Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni...
Source: NCGC
Target: N/A
External Id: CPF001

Total 55, Current Page 1 of 6

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

GIT 27

3-phenyl-4,5-dihydro-5-isoxazoleacetic acid

4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID

(3-Phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid

VGX-1027

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid?

A: SMILES notation of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid is O=C(O)CC1CC(c2ccccc2)=NO1.

Q: What is the Chinese name of 6501-72-0?

A: Chinese name of 6501-72-0 is VGX-1027.

Q: What is the molecular formula of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid?

A: Molecular formula of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid is C11H11NO3.

Q: What is the LogP of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid?

A: LogP of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid is 1.16.

Q: What is the molecular weight of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid?

A: Molecular weight of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid is 205.210.

Q: What is the CAS number of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid?

A: CAS number of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid is 6501-72-0.

Q: What is the boiling point of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid?

A: Boiling point of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid is 381.4±34.0 °C at 760 mmHg.

Q: What is the InChIKey of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid?

A: InChIKey of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid is MUFJHYRCIHHATF-UHFFFAOYSA-N.

Q: What are the upstream materials of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid?

A: Related upstream materials(CAS) of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid: 625-38-7;613-91-2;698-16-8.

Q: What English synonyms does 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid have?

A: English synonyms of 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid: GIT 27, 3-phenyl-4,5-dihydro-5-isoxazoleacetic acid, 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID, (3-Phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid, VGX-1027.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: VGX-1027(Git-27)
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

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Price: $112/10mM*1mLinDMSO

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.