Enoxaparin sodium
Enoxaparin sodium structure
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Common Name | Enoxaparin sodium | ||
|---|---|---|---|---|
| CAS Number | 679809-58-6 | Molecular Weight | 1134.92788 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H42N2O37S5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Enoxaparin sodiumEnoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19[1][2][3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Enoxaparin sodium |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19[1][2][3]. |
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| Related Catalog | |
| In Vitro | Enoxaparin (0-70 µg/mL, 90 min) enhances AAT (alpha-1-antitrypsin) inhibition of both TMPRSS2 (Transmembrane Protease 2) activity and infection of hAEc (human airway epithelial cells) with HCoV-229E[1]. Cell Viability Assay[1] Cell Line: HEK293T TMPRSS2 cells, hAEc Concentration: 0, 8.8, 35, 70 µg/mL Incubation Time: 90 min Result: Significantly inhibited TMPRSS2 activity at the 90 min incubation period at 35 and 70 µg/mL, enhanced AAT inhibition of TMPRSS2 activity, and augmented AAT inhibition of HCoV-229E infection of hAEc. |
| In Vivo | Enoxaparin (1 mg/kg; SC; once every 6 h for 8 times) reduces oxidative damage, inflammation and astrocytosis following TBI (traumatic brain injury) in the rat[2]. Animal Model: Adult male Wistar rats (350-450 g, TBI-treated)[2] Dosage: 0 mg/kg, 1 mg/kg Administration: SC, once every 6 h, starting at 1 h, and finishing at 43 h after the TBI induction. Result: Significantly decreased the hippocampal TBARS and oxidized protein levels, COX-2 overexpression and reactive gliosis, but it did not influence the SOD and GSH-Px activities, pro-IL-1β and active caspase-3 overexpressions as well as neurodegeneration following TBI. Reduce oxidative damage, inflammation and astrocytosis following TBI in the rat. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C26H42N2O37S5 |
|---|---|
| Molecular Weight | 1134.92788 |
| InChIKey | CIJQTPFWFXOSEO-UHFFFAOYSA-J |
| SMILES | CC(=O)NC1C(OC2C(C(=O)[O-])OC(OC3C4COC(O4)C(NS(=O)(=O)[O-])C3O)C(O)C2O)OC(CO)C(OC2CC(C(=O)[O-])C(OC3OC(COS(=O)(=O)O)C(OC4OC(C(=O)[O-])=CC(O)C4O)C(O)C3NC(C)=O)C(O)C2O)C1C.[Na+].[Na+].[Na+].[Na+] |
| Storage condition | -20℃ |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Clexane |
| Enoxaparin |
| Enoxil |
| Klexane |
| Lovenox |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of Enoxaparin sodium? |
| A: Main uses of Enoxaparin sodium: Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19[1][2][3]. |
| Q: What English synonyms does Enoxaparin sodium have? |
| A: English synonyms of Enoxaparin sodium: Clexane, Enoxaparin, Enoxil, Klexane, Lovenox. |
| Q: What is the molecular formula of Enoxaparin sodium? |
| A: Molecular formula of Enoxaparin sodium is C26H42N2O37S5. |
| Q: What is the molecular weight of Enoxaparin sodium? |
| A: Molecular weight of Enoxaparin sodium is 1134.92788. |
| Q: What is the SMILES notation of Enoxaparin sodium? |
| A: SMILES notation of Enoxaparin sodium is CC(=O)NC1C(OC2C(C(=O)[O-])OC(OC3C4COC(O4)C(NS(=O)(=O)[O-])C3O)C(O)C2O)OC(CO)C(OC2CC(C(=O)[O-])C(OC3OC(COS(=O)(=O)O)C(OC4OC(C(=O)[O-])=CC(O)C4O)C(O)C3NC(C)=O)C(O)C2O)C1C.[Na+].[Na+].[Na+].[Na+]. |
| Q: What are the storage conditions for Enoxaparin sodium? |
| A: Storage conditions for Enoxaparin sodium: -20℃. |
| Q: What is the InChIKey of Enoxaparin sodium? |
| A: InChIKey of Enoxaparin sodium is CIJQTPFWFXOSEO-UHFFFAOYSA-J. |
| Q: What is the CAS number of Enoxaparin sodium? |
| A: CAS number of Enoxaparin sodium is 679809-58-6. |
| Q: What is the English name of Enoxaparin sodium? |
| A: The English name of Enoxaparin sodium is Enoxaparin sodium. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |