Isradipine
Isradipine structure
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Common Name | Isradipine | ||
|---|---|---|---|---|
| CAS Number | 75695-93-1 | Molecular Weight | 371.387 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 501.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C19H21N3O5 | Melting Point | 166-168°C | |
| MSDS | Chinese USA | Flash Point | 257.4±32.9 °C | |
Use of IsradipineIsradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.Target: Calcium ChannelIsradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack[1]. Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension [2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Isradipine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.Target: Calcium ChannelIsradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack[1]. Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension [2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 501.9±60.0 °C at 760 mmHg |
| Melting Point | 166-168°C |
| Molecular Formula | C19H21N3O5 |
| Molecular Weight | 371.387 |
| Flash Point | 257.4±32.9 °C |
| Exact Mass | 371.148132 |
| PSA | 103.55000 |
| LogP | 3.59 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.566 |
| InChIKey | HMJIYCCIJYRONP-UHFFFAOYSA-N |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: ~26 mg/mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Isradipine CAS#:75695-93-1 |
| Literature: WO2005/5437 A1, ; Page/Page column 7-9 ; |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.
Brain 137(Pt 8) , 2287-302, (2014) Dopamine midbrain neurons within the substantia nigra are particularly prone to degeneration in Parkinson's disease. Their selective loss causes the major motor symptoms of Parkinson's disease, but th... |
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Analysis of responses to the TRPV4 agonist GSK1016790A in the pulmonary vascular bed of the intact-chest rat.
Am. J. Physiol. Heart Circ. Physiol. 306(1) , H33-40, (2014) The transient receptor potential vanilloid 4 (TRPV4) channel is a nonselective cation channel expressed on many cell types, including the vascular endothelium and smooth muscle cells. TRPV4 channels p... |
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L-type calcium channel blockade alleviates molecular and reversal spatial learning and memory alterations induced by entorhinal amyloid pathology in rats.
Behav. Brain Res. 237 , 190-9, (2013) The entorhinal cortex (EC) is one of the most vulnerable brain regions that is affected by beta amyloid (Aβ) in the early phases of Alzheimer's disease (AD). Calcium dyshomeostasis is one reason of Aβ... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylate |
| Rebriden |
| DynaCirc |
| 4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester |
| Esradin |
| Isrodipine |
| 4-(2,1,3-Benzooxadiazol-4-yl)-2.6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester |
| Presca |
| 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester (9CI) |
| Dynacrine |
| MFCD00153820 |
| Rebfiden |
| Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic AcidMethyl 1-Methylethyl Ester |
| Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate |
| Iomir |
| methyl propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-isopropyloxycarbonyl-pyridine-5-carboxylic acid methyl ester |
| Clivoten |
| UNII:YO1UK1S598 |
| 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-pyridine-5-carboxylic acid isopropyl ester |
| Lomir |
| 4-(2,1,3-benzoxadiazol-4-yl)-2,6-diméthyl-1,4-dihydropyridine-3,5-dicarboxylate de méthyle et de 1-méthyléthyle |
| 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester |
| Methyl-1-methylethyl-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarboxylat |
| Isradipine |
| methyl 1-methylethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| Prescal |
| Isradipin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of Isradipine? |
| A: SMILES notation of Isradipine is COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12. |
| Q: What is the molecular weight of Isradipine? |
| A: Molecular weight of Isradipine is 371.387. |
| Q: What is the molecular formula of Isradipine? |
| A: Molecular formula of Isradipine is C19H21N3O5. |
| Q: What is the polar surface area (PSA) of Isradipine? |
| A: Polar surface area (PSA) of Isradipine is 103.55000. |
| Q: What is the InChIKey of Isradipine? |
| A: InChIKey of Isradipine is HMJIYCCIJYRONP-UHFFFAOYSA-N. |
| Q: What is the English name of Isradipine? |
| A: The English name of Isradipine is Isradipine. |
| Q: How is the water solubility of Isradipine? |
| A: Water solubility of Isradipine: DMSO: ~26 mg/mL. |
| Q: What is the safety information for Isradipine? |
| A: Safety information for Isradipine: S22-S24/25. |
| Q: What is the melting point of Isradipine? |
| A: Melting point of Isradipine is 166-168°C. |
| Q: What is the LogP of Isradipine? |
| A: LogP of Isradipine is 3.59. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |