TUG 891
Modify Date: 2025-08-25 20:53:23
TUG 891 structure
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Common Name | TUG 891 | ||
|---|---|---|---|---|
| CAS Number | 1374516-07-0 | Molecular Weight | 364.40900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H21FO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TUG 891TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4. |
| Name | 3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic a cid |
|---|---|
| Synonym | More Synonyms |
| Description | TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4. |
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| Related Catalog | |
| In Vitro | TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1]. |
| References |
| Molecular Formula | C23H21FO3 |
|---|---|
| Molecular Weight | 364.40900 |
| Exact Mass | 364.14700 |
| PSA | 46.53000 |
| LogP | 5.39730 |
| InChIKey | LPGBXHWIQNZEJB-UHFFFAOYSA-N |
| SMILES | Cc1ccc(-c2ccc(F)cc2COc2ccc(CCC(=O)O)cc2)cc1 |
| Storage condition | 2-8℃ |
|
~95%
TUG 891 CAS#:1374516-07-0 |
| Literature: Shimpukade, Bharat; Hudson, Brian D.; Hovgaard, Christine Kiel; Milligan, Graeme; Ulven, Trond Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4511 - 4515 |
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~%
TUG 891 CAS#:1374516-07-0 |
| Literature: Shimpukade, Bharat; Hudson, Brian D.; Hovgaard, Christine Kiel; Milligan, Graeme; Ulven, Trond Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4511 - 4515 |
|
~%
TUG 891 CAS#:1374516-07-0 |
| Literature: Shimpukade, Bharat; Hudson, Brian D.; Hovgaard, Christine Kiel; Milligan, Graeme; Ulven, Trond Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4511 - 4515 |
![Methyl 3-(4-{[5-fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoate structure](https://www.chemsrc.com/extcaspic/067/1374516-35-4.png)
| Precursor 2 | |
|---|---|
| DownStream 0 | |
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Name: Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGF...
Source: ChEMBL
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External Id: CHEMBL5303712
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Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
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Name: Incucyte cell viability with HEK293T
Source: ChEMBL
Target: HEK-293T
External Id: CHEMBL5058565
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|
Name: Antagonist activity at human FFAR4 expressed in CHO cells assessed as inhibition of T...
Source: ChEMBL
Target: Free fatty acid receptor 4
External Id: CHEMBL4015239
|
|
Name: Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recr...
Source: ChEMBL
Target: Free fatty acid receptor 4
External Id: CHEMBL4015237
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Name: Thermal Shift Assay. Domain: start/stop: M626-G740
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL5062517
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Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5065589
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Name: Thermal Shift Assay. Domain: start/stop: S229-K512
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL5060015
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|
Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209827
|
|
Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209826
|
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| tug-770 |
| TUG 891 |
| TUG-891 |
| TUG891 |