RSV-604
Modify Date: 2025-08-27 13:15:09
RSV-604 structure
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Common Name | RSV-604 | ||
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| CAS Number | 676128-63-5 | Molecular Weight | 388.39400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H17FN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RSV-604RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.IC50 value: 0.86 uM(EC50) [1]Target: RSV inhibitorRSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease. |
| Name | (S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea |
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| Synonym | More Synonyms |
| Description | RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.IC50 value: 0.86 uM(EC50) [1]Target: RSV inhibitorRSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease. |
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| Related Catalog | |
| References |
| Molecular Formula | C22H17FN4O2 |
|---|---|
| Molecular Weight | 388.39400 |
| Exact Mass | 388.13400 |
| PSA | 82.59000 |
| LogP | 3.80050 |
| InChIKey | MTPVBMVUENFFLL-HXUWFJFHSA-N |
| SMILES | O=C(Nc1ccccc1F)NC1N=C(c2ccccc2)c2ccccc2NC1=O |
| Storage condition | 2-8℃ |
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Name: NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C...
Source: NCGC
Target: N/A
External Id: adst_HEK293_Anti-infectives-02
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Name: NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay
Source: NCGC
Target: N/A
External Id: adst_Celegans_Anti-infectives-o1
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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Name: Therapeutic index, CC50 for human Hep2 cells to EC50 for RSV RSS
Source: ChEMBL
Target: N/A
External Id: CHEMBL993163
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Name: Antiviral activity against RSV RSS in Hep2 cells by XTT assay
Source: ChEMBL
Target: Respiratory syncytial virus
External Id: CHEMBL917119
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Name: Antiviral activity against RSV infected human Hep2 cells assessed as reduction of pla...
Source: ChEMBL
Target: Respiratory syncytial virus
External Id: CHEMBL993172
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Name: Antiviral activity against RSV RSS in Hep2 cells by ELISA
Source: ChEMBL
Target: Respiratory syncytial virus
External Id: CHEMBL918026
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Name: Antiviral activity against RSV RSS in Hep2 cells by plaque assay
Source: ChEMBL
Target: Respiratory syncytial virus
External Id: CHEMBL918027
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Name: ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301363
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| rsv604 |
| rsv-604 |