JNJ 63533054
Modify Date: 2025-08-26 10:36:42
JNJ 63533054 structure
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Common Name | JNJ 63533054 | ||
|---|---|---|---|---|
| CAS Number | 1802326-66-4 | Molecular Weight | 316.782 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 559.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H17ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 292.3±28.7 °C | |
Use of JNJ 63533054JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.IC50 value: 16 nM (EC50)Target: hGPR139in vitro: JNJ-63533054 is a selective small-molecule agonist. JNJ-63533054 specifically activates human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. [2] JNJ-63533054 is found to be clean of any cross reactivity as judged by an external selectivity panel of 50 known GPCRs, ion channels, and transporters as well as our own internal whole cell lead generation biology selectivity panel.[1]in vivo: JNJ-63533054 is found to cross the blood-brain barrier and have good drug-like properties amenable for oral dosing in rat. JNJ-63533054 exhibits good stability in both human and rat microsomes and high solubility in aqueous media, and no DDI potential was found. [1] JNJ-63533054 also activates the rat and mouse GPR139 receptor with similar potency (rat EC50 = 63 ± 24 nM, mouse EC50 = 28 ± 7 nM). [2] |
| Name | 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide |
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| Synonym | More Synonyms |
| Description | JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.IC50 value: 16 nM (EC50)Target: hGPR139in vitro: JNJ-63533054 is a selective small-molecule agonist. JNJ-63533054 specifically activates human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. [2] JNJ-63533054 is found to be clean of any cross reactivity as judged by an external selectivity panel of 50 known GPCRs, ion channels, and transporters as well as our own internal whole cell lead generation biology selectivity panel.[1]in vivo: JNJ-63533054 is found to cross the blood-brain barrier and have good drug-like properties amenable for oral dosing in rat. JNJ-63533054 exhibits good stability in both human and rat microsomes and high solubility in aqueous media, and no DDI potential was found. [1] JNJ-63533054 also activates the rat and mouse GPR139 receptor with similar potency (rat EC50 = 63 ± 24 nM, mouse EC50 = 28 ± 7 nM). [2] |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 559.7±45.0 °C at 760 mmHg |
| Molecular Formula | C17H17ClN2O2 |
| Molecular Weight | 316.782 |
| Flash Point | 292.3±28.7 °C |
| Exact Mass | 316.097870 |
| LogP | 3.13 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.586 |
| InChIKey | MWDVCHRYCKXEBY-LBPRGKRZSA-N |
| SMILES | CC(NC(=O)CNC(=O)c1cccc(Cl)c1)c1ccccc1 |
| Storage condition | 2-8℃ |
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Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
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Name: Thermal Shift Assay. Domain: start/stop: M1-K294
Source: ChEMBL
Target: Casein kinase I isoform delta
External Id: CHEMBL5064333
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Name: Incucyte cell viability with HEK293T
Source: ChEMBL
Target: HEK-293T
External Id: CHEMBL5058565
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Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5065589
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Name: Thermal Shift Assay. Domain: start/stop: S229-K512
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL5060015
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Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209827
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Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209826
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|
Name: GPCR beta-arrestin recruitment assay with target: GLP1R Assay Type: PRESTO-Tango Conc...
Source: ChEMBL
Target: Glucagon-like peptide 1 receptor
External Id: CHEMBL5209829
|
|
Name: Thermal Shift Assay. Domain: start/stop: G861-E979
Source: ChEMBL
Target: Transcription intermediary factor 1-alpha
External Id: CHEMBL5068978
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Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209828
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| 3-Chloro-N-(2-oxo-2-{[(1S)-1-phenylethyl]amino}ethyl)benzamide |
| JNJ-63533054 |