DB07268

Modify Date: 2025-10-01 12:17:47

DB07268 structure	Common Name	DB07268
	CAS Number	929007-72-7	Molecular Weight	321.333
	Density	1.4±0.1 g/cm3	Boiling Point	641.6±65.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₅N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	341.8±34.3 °C

Use of DB07268

DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.

Name	2-({2-[(3-Hydroxyphenyl)amino]-4-pyrimidinyl}amino)benzamide
Synonym	More Synonyms

Description	DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> JNK Research Areas >> Cancer
Target	JNK1:9 nM (IC50) CHK1:0.82 μM (IC50) PAK4:5.5 μM (IC50) AKT1:15 μM (IC50) ERK2:25 μM (IC50)
In Vitro	DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively[1].
References	[1]. Liu M, et al. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72.

Density	1.4±0.1 g/cm3
Boiling Point	641.6±65.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₅N₅O₂
Molecular Weight	321.333
Flash Point	341.8±34.3 °C
Exact Mass	321.122589
LogP	1.96
Appearance of Characters	light yellow solid
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.753
InChIKey	QHPKKGUGRGRSGA-UHFFFAOYSA-N
SMILES	NC(=O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1
Storage condition	-20°C

Name: Inhibition of JNK1 (unknown origin) expressed in HEK293 cells assessed as anisomycin-...
Source: ChEMBL
Target: Mitogen-activated protein kinase 8
External Id: CHEMBL3751433

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Inhibition of JNK1 (unknown origin) expressed in HEK293 cells assessed as anisomycin-...
Source: ChEMBL
Target: Mitogen-activated protein kinase 8
External Id: CHEMBL3751432

Name: Inhibition of JNK1 (unknown origin)
Source: ChEMBL
Target: Mitogen-activated protein kinase 8
External Id: CHEMBL3751431

Name: Experimentally measured binding affinity data (IC50) for protein-ligand complexes der...
Source: Shanghai Institute of Organic Chemistry
Target: N/A
External Id: PDBbind-IC50 for protein-ligand complexes

Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437

Name: Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13
Source: NCGC
Target: N/A
External Id: ACC-ATC-p1-SW13-72hr

Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395

Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536

Name: Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R
Source: NCGC
Target: N/A
External Id: ACC-ATC-p1-H295R-72hr

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2-({2-[(3-Hydroxyphenyl)amino]-4-pyrimidinyl}amino)benzamide

MFCD26960941

DB07268

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DB07268
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-((2-((3-hydroxyphenyl)amino)pyrimidin-4-yl)amino)benzamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: $158/10mM*1mLinDMSO

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DB07268

Use of DB07268

Names

DB07268 Biological Activity

Chemical & Physical Properties

DB07268Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.