Cyclosporin H

Modify Date: 2025-09-05 18:57:30

Cyclosporin H Structure
Cyclosporin H structure
Common Name Cyclosporin H
CAS Number 83602-39-5 Molecular Weight 1216.638
Density 1.0±0.1 g/cm3 Boiling Point 1282.0±65.0 °C at 760 mmHg
Molecular Formula C62H111N11O12 Melting Point 162-165ºC
MSDS N/A Flash Point 729.1±34.3 °C

 Use of Cyclosporin H


Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin or prostaglandin E2. Cyclosporin H lacks immunosuppressant activity of cyclosporin A.

 Names

Name Cyclosporin H
Synonym More Synonyms

 Cyclosporin H Biological Activity

Description Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin or prostaglandin E2. Cyclosporin H lacks immunosuppressant activity of cyclosporin A.
Related Catalog

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 1282.0±65.0 °C at 760 mmHg
Melting Point 162-165ºC
Molecular Formula C62H111N11O12
Molecular Weight 1216.638
Flash Point 729.1±34.3 °C
Exact Mass 1215.857056
PSA 270.01000
LogP 4.28
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.469
InChIKey PMATZTZNYRCHOR-JLPRAAIDSA-N
SMILES CC=CCC(C)C(O)C1C(=O)NC(CC)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)N1C

 Cyclosporin HBioassay

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Name: Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ...
Source: NCGC
External Id: s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1
Name: Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 ce...
Source: NCGC
External Id: s-sky_synergy-MV-411_N-CTG72-MIPE_NPC_NPACT_Kinase-p1
Name: Apparent permeability in low-efflux MDCK2 cells at 2 uM by lucifer yellow dye-based U...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4328888
Name: 1,9-decadiene/aqueous buffer solution partition coefficient, log D of the compound in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4328887
Name: Thermodynamic aqueous solubility of compound in pH 7.4 PBS by UPLC-MS analysis
Source: ChEMBL
Target: N/A
External Id: CHEMBL4328886
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 Synonyms

(3S,6S,9S,12R,15S,18S,21R,24S,30S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,22,25,28-decamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
CyclosporinH
cyclosiversioside H
Cyclosporin Impurity 8
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