Cyclosporin H

Names

[ Name ]:
Cyclosporin H

[Synonym ]:
(3S,6S,9S,12R,15S,18S,21R,24S,30S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,22,25,28-decamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
CyclosporinH
1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-1,4,7,10,12,15,19,22,25,28-decamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-, (3S,6S,9S,12R,15S,18S,21R,24S,30S)-
cyclosiversioside H
Cyclosporin Impurity 8

Biological Activity

[Description]:

Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin or prostaglandin E2. Cyclosporin H lacks immunosuppressant activity of cyclosporin A.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
1282.0±65.0 °C at 760 mmHg

[ Melting Point ]:
162-165ºC

[ Molecular Formula ]:
C₆₂H₁₁₁N₁₁O₁₂

[ Molecular Weight ]:
1216.638

[ Flash Point ]:
729.1±34.3 °C

[ Exact Mass ]:
1215.857056

[ PSA ]:
270.01000

[ LogP ]:
4.28

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.469

Related Compounds

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