Finerenone

Modify Date: 2025-08-24 19:56:37

Finerenone structure	Common Name	Finerenone
	CAS Number	1050477-31-0	Molecular Weight	378.42400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₂N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Finerenone

Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease[1][2].

Name	(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
Synonym	More Synonyms

Description	Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor
In Vivo	Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Frömter (MWF) rat[1]. Animal Model: Twelve-week-old MWF rat[1] Dosage: 10 mg/kg Administration: P.o.; daily for 4 weeks Result: Significantly reduced SBP in MWF rats; led to a significant reduction (>40%) in albuminuria in the MWF model. Animal Model: Twelve-week-old MWF rat[1] Dosage: 10 mg/kg Administration: P.o.; daily for 4 weeks Result: Significantly reduced SBP in MWF rats; led to a significant reduction (>40%) in albuminuria in the MWF model.
References	[1]. Bärfacker L, et al. Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem. 2012;7(8):1385-1403. [2]. González-Blázquez R, et al. Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress. Front Pharmacol. 2018;9:1131. Published 2018 Oct 9.

Molecular Formula	C₂₁H₂₂N₄O₃
Molecular Weight	378.42400
Exact Mass	378.16900
PSA	111.25000
LogP	4.27338

Hazard Codes	T+

Name: Human Mineralocorticoid receptor (3C. 3-Ketosteroid receptors)
Source: IUPHAR-DB
Target: Mineralocorticoid receptor (3C. 3-Ketosteroid receptors) [Homo sapiens]
External Id: 626_Human

Name: ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301363

Name: ASTRAZENECA: Most basic pKa value (pKa B1) determined by absorption and potentiometri...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301362

Name: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301365

Name: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301366

Name: Induction of improvement in urinary albumin-creatinine ratio in patient with diabetic...
Source: ChEMBL
Target: Homo sapiens
External Id: CHEMBL4008047

Name: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301368

Name: ASTRAZENECA: Intrinsic clearance measured in rat hepatocytes following incubation at ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301371

Name: Ratio of IC50 for Gal4-fused human MR Ser810 mutant expressed in HEK293T cells to IC5...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4008017

Name: ASTRAZENECA: Intrinsic clearance measured in human liver microsomes following incubat...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301370

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Finerenone

UNII-DE2O63YV8R

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Finerenone
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Finerenone (BAY 94-8862)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.