SNDX-5613

Modify Date: 2025-08-25 19:39:02

SNDX-5613 structure	Common Name	SNDX-5613
	CAS Number	2169919-21-3	Molecular Weight	630.82
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₄₇FN₆O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SNDX-5613

SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].

Name	SNDX-5613

Description	SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	Menin-MLL[1]
In Vivo	SNDX-5613 shows in vivo plasma IC50 of 53 nM. SNDX-5613 treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts[1].
References	[1]. A drug, SNDX-5613, to treat acute leukemia with a KMT2A translocation or an NPM1 mutation that has come back (relapsed) or has not gotten better with treatment (refractory).

Molecular Formula	C₃₂H₄₇FN₆O₄S
Molecular Weight	630.82
Storage condition	-20°C

Name: Thermal Shift Assay. Domain: start/stop: S229-K512
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL5060015

Name: Thermal Shift Assay. Domain: start/stop: N44-E168
Source: ChEMBL
Target: Bromodomain-containing protein 4
External Id: CHEMBL5060944

Name: Thermal Shift Assay. Domain start/stop: M626-G740
Source: ChEMBL
Target: Peregrin
External Id: CHEMBL4650107

Name: Incucyte cell viability with human fibroblast
Source: ChEMBL
Target: Fibroblast
External Id: CHEMBL4725213

Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802

Name: Incucyte cell viability with HEK293T
Source: ChEMBL
Target: HEK-293T
External Id: CHEMBL4725212

Name: Incucyte cell viability with U2OS
Source: ChEMBL
Target: U2OS
External Id: CHEMBL4725214

Name: Thermal Shift Assay. Domain: start/stop: E122-S403
Source: ChEMBL
Target: Aurora kinase A
External Id: CHEMBL5067447

Name: Thermal Shift Assay. Domain: start/stop: G861-E979
Source: ChEMBL
Target: Transcription intermediary factor 1-alpha
External Id: CHEMBL5068376

Name: Thermal Shift Assay. Domain: start/stop: M1-K294
Source: ChEMBL
Target: Casein kinase I isoform delta
External Id: CHEMBL5063731

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SNDX-5613
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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Price: ￥5000/5 mg

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SNDX-5613

Use of SNDX-5613

Names

SNDX-5613 Biological Activity

Chemical & Physical Properties

SNDX-5613Bioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.