SNDX-5613
Names
[ CAS No. ]:
2169919-21-3
[ Name ]:
SNDX-5613
Biological Activity
[Description]:
SNDX-5613 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].
[Related Catalog]:
[Target]
Menin-MLL[1]
[In Vivo]
SNDX-5613 shows in vivo plasma IC50 of 53 nM. SNDX-5613 treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C32H47FN6O4S
[ Molecular Weight ]:
630.82
[ Storage condition ]:
-20°C
Related Compounds
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.