MMAD
Modify Date: 2025-08-25 17:16:57
MMAD structure
|
Common Name | MMAD | ||
|---|---|---|---|---|
| CAS Number | 203849-91-6 | Molecular Weight | 771.064 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 906.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C41H66N6O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 501.8±34.3 °C | |
Use of MMADMMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs). |
| Name | Monomethylauristatin D |
|---|---|
| Synonym | More Synonyms |
| Description | MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs). |
|---|---|
| Related Catalog | |
| Target |
Tubulin[1] |
| In Vitro | MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1]. |
| In Vivo | The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 906.1±65.0 °C at 760 mmHg |
| Molecular Formula | C41H66N6O6S |
| Molecular Weight | 771.064 |
| Flash Point | 501.8±34.3 °C |
| Exact Mass | 770.476440 |
| LogP | 5.82 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.537 |
| InChIKey | BLUGYPPOFIHFJS-UUFHNPECSA-N |
| SMILES | CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(Cc1ccccc1)c1nccs1)OC)N(C)C(=O)C(NC(=O)C(NC)C(C)C)C(C)C |
| Storage condition | 2-8℃ |
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Name: Apparent intrinsic clearance in human liver hepatocytes at 1 uM
Source: ChEMBL
Target: Hepatocyte
External Id: CHEMBL3390356
|
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Name: Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore...
Source: ChEMBL
Target: MDA-MB-361
External Id: CHEMBL3390353
|
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Name: Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 da...
Source: ChEMBL
Target: BT-474
External Id: CHEMBL3390352
|
|
Name: Apparent intrinsic clearance in human liver microsomes at 1 uM
Source: ChEMBL
Target: Liver microsome
External Id: CHEMBL3390355
|
|
Name: Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 ...
Source: ChEMBL
Target: NCI-N87
External Id: CHEMBL3390354
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| N-Methyl-L-valyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]-1-pyrrolidinyl}-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide |
| MFCD25976743 |
| Demethyldolastatin 10 |
| Monomethylauristatin D |
| Monomethyl Dolastatin 10 |
| MMAD |