ABBV-744

Published date: 2022-11-29 15:44:27
ABBV-744 Structure
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Name ABBV-744 CAS# 2138861-99-9
Price ￥Inquiry/1g Purity 98.9%
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Period		 1 Day Stock In Stock
 Detail Product Information
ABBV-744 is a BDII-selective BET bromodomain inhibitor that is being investigated to treat AML and metastic castration-resistant prostate cancer.BBV-744, a highly potent and selective inhibitor of the BD2 domain of BET family proteins with drug-like properties. In contrast to the broad range of cell growth inhibition induced by DbBi, the antiproliferative activity of ABBV-744 was largely, but not exclusively, restricted to cell lines of acute myeloid leukaemia and prostate cancer that expressed the full-length androgen receptor (AR). ABBV-744 retained robust activity in prostate cancer xenografts, and showed fewer platelet and gastrointestinal toxicities than the DbBi ABBV-07514.Analyses of RNA expression and chromatin immunoprecipitation followed by sequencing revealed that ABBV-744 displaced BRD4 from AR-containing super-enhancers and inhibited AR-dependent transcription, with less impact on global transcription compared with ABBV-075. These results underscore the potential value of selectively targeting the BD2 domain of BET family proteins for cancer therapy.
Supplier/Manufacture

ShangHai DC Chemicals Co.,Ltd verified supplier

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2024-07-15 ABBV-744
Price: Inquiry
2020-01-06 ABBV-744
Price: $600.0
2022-01-13 ABBV744
Price: ￥Inquiry
2023-10-19 ABBV744
Price: ￥Inquiry
2022-11-03 ABBV-744
Price: ￥4000.0
2021-04-03 ABBV-744
Price: ￥1715.0

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